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Peculiar characteristics of new-onset Type 1 Diabetes during COVID-19 pandemic
BACKGROUND: The COVID-19 pandemic period is having a strong impact on the management of diabetes as well as other chronic diseases as shown by the most severe clinical presentation at onset. The aim of this study was to evaluate the severity of diabetic ketoacidosis (DKA) in youth with newly diagnos...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8827260/ https://www.ncbi.nlm.nih.gov/pubmed/35139895 http://dx.doi.org/10.1186/s13052-022-01223-8 |
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author | Mastromauro, Concetta Blasetti, Annalisa Primavera, Marina Ceglie, Lucio Mohn, Angelika Chiarelli, Francesco Giannini, Cosimo |
author_facet | Mastromauro, Concetta Blasetti, Annalisa Primavera, Marina Ceglie, Lucio Mohn, Angelika Chiarelli, Francesco Giannini, Cosimo |
author_sort | Mastromauro, Concetta |
collection | PubMed |
description | BACKGROUND: The COVID-19 pandemic period is having a strong impact on the management of diabetes as well as other chronic diseases as shown by the most severe clinical presentation at onset. The aim of this study was to evaluate the severity of diabetic ketoacidosis (DKA) in youth with newly diagnosed type 1 diabetes in “Santissima Annunziata Hospital” (Chieti, Italy) during COVID-19 pandemic in comparison to the five previous years. METHODS: A retrospective population-based incidence study was performed. Data were obtained from hospital records of 172 patients with new onset type 1 diabetes divided into two groups according to the diagnosis: Group I, between January 2015 and February 2020; Group II, between March 2020 and April 2021. Data regarding anthropometric, socio-economic and laboratory test were analyzed. DKA (pH < 7.30) and different severity of the disease (severe pH < 7.10; moderate pH < 7.20, mild pH < 7.30) were evaluated. A Spearman correlation between pH values and the main variables of interest was performed. RESULTS: DKA frequency was increased by 19 percentage in Group II compared to Group I (55% vs 36%; P = 0.03) with a significant increased risk of severe DKA cases compared to the previous five years (severe DKA 22.5% vs. 8.4%, P = 0.01). pH values were significantly related with HbA1c, blood glucose and c-peptide values in all groups. In addition, in Group II but not in Group I, pH values correlated with Triglycerides and TG/HDL cholesterol ratio. CONCLUSIONS: During COVID-19 pandemic the risk of more severe clinical presentation of type 1 diabetes at onset is increased. The correlation with lipid profile might suppose an additional effect of lifestyle changes beside the delay in the diagnosis. Modifications of health care system need to be implemented during this peculiar situation in order to avoid such a relevant complication at onset. |
format | Online Article Text |
id | pubmed-8827260 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-88272602022-02-10 Peculiar characteristics of new-onset Type 1 Diabetes during COVID-19 pandemic Mastromauro, Concetta Blasetti, Annalisa Primavera, Marina Ceglie, Lucio Mohn, Angelika Chiarelli, Francesco Giannini, Cosimo Ital J Pediatr Research BACKGROUND: The COVID-19 pandemic period is having a strong impact on the management of diabetes as well as other chronic diseases as shown by the most severe clinical presentation at onset. The aim of this study was to evaluate the severity of diabetic ketoacidosis (DKA) in youth with newly diagnosed type 1 diabetes in “Santissima Annunziata Hospital” (Chieti, Italy) during COVID-19 pandemic in comparison to the five previous years. METHODS: A retrospective population-based incidence study was performed. Data were obtained from hospital records of 172 patients with new onset type 1 diabetes divided into two groups according to the diagnosis: Group I, between January 2015 and February 2020; Group II, between March 2020 and April 2021. Data regarding anthropometric, socio-economic and laboratory test were analyzed. DKA (pH < 7.30) and different severity of the disease (severe pH < 7.10; moderate pH < 7.20, mild pH < 7.30) were evaluated. A Spearman correlation between pH values and the main variables of interest was performed. RESULTS: DKA frequency was increased by 19 percentage in Group II compared to Group I (55% vs 36%; P = 0.03) with a significant increased risk of severe DKA cases compared to the previous five years (severe DKA 22.5% vs. 8.4%, P = 0.01). pH values were significantly related with HbA1c, blood glucose and c-peptide values in all groups. In addition, in Group II but not in Group I, pH values correlated with Triglycerides and TG/HDL cholesterol ratio. CONCLUSIONS: During COVID-19 pandemic the risk of more severe clinical presentation of type 1 diabetes at onset is increased. The correlation with lipid profile might suppose an additional effect of lifestyle changes beside the delay in the diagnosis. Modifications of health care system need to be implemented during this peculiar situation in order to avoid such a relevant complication at onset. BioMed Central 2022-02-09 /pmc/articles/PMC8827260/ /pubmed/35139895 http://dx.doi.org/10.1186/s13052-022-01223-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Mastromauro, Concetta Blasetti, Annalisa Primavera, Marina Ceglie, Lucio Mohn, Angelika Chiarelli, Francesco Giannini, Cosimo Peculiar characteristics of new-onset Type 1 Diabetes during COVID-19 pandemic |
title | Peculiar characteristics of new-onset Type 1 Diabetes during COVID-19 pandemic |
title_full | Peculiar characteristics of new-onset Type 1 Diabetes during COVID-19 pandemic |
title_fullStr | Peculiar characteristics of new-onset Type 1 Diabetes during COVID-19 pandemic |
title_full_unstemmed | Peculiar characteristics of new-onset Type 1 Diabetes during COVID-19 pandemic |
title_short | Peculiar characteristics of new-onset Type 1 Diabetes during COVID-19 pandemic |
title_sort | peculiar characteristics of new-onset type 1 diabetes during covid-19 pandemic |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8827260/ https://www.ncbi.nlm.nih.gov/pubmed/35139895 http://dx.doi.org/10.1186/s13052-022-01223-8 |
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