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Trigonelline reverses high glucose-induced proliferation, fibrosis of mesangial cells via modulation of Wnt signaling pathway

BACKGROUND: Diabetic nephropathy (DN) is the leading cause of the end-stage renal disease (ESRD). The proliferation and apoptosis of mesangial cells induced by the activated Wnt/β-catenin pathway is crucial in DN. Trigonelline (TRL) is an alkaloid that has been shown to decrease proteinuria and prot...

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Detalles Bibliográficos
Autores principales:	Chen, Chen, Shi, Yan, Ma, Jiulong, Chen, Zhen, Zhang, Ming, Zhao, Yan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8827266/ https://www.ncbi.nlm.nih.gov/pubmed/35139912 http://dx.doi.org/10.1186/s13098-022-00798-w

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