Direct comparison of the next-generation sequencing and iTERT PCR methods for the diagnosis of TERT hotspot mutations in advanced solid cancers

BACKGROUND: Mutations in the telomerase reverse transcriptase (TERT) promoter region have been proposed as novel mechanisms for the transcriptional activation of telomerase. Two recurrent mutations in the TERT promoter, C228T and C250T, are prognostic biomarkers. Herein, we directly compared the com...

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Detalles Bibliográficos
Autores principales: Kang, So Young, Kim, Deok Geun, Kim, Hyunjin, Cho, Yoon Ah, Ha, Sang Yun, Kwon, Ghee Young, Jang, Kee-Taek, Kim, Kyoung-Mee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8827275/
https://www.ncbi.nlm.nih.gov/pubmed/35135543
http://dx.doi.org/10.1186/s12920-022-01175-2

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