Synthesis of aromatic lactone analogues of Lipoxin A4

OBJECTIVE: Synthesis of novel aromatic Lipoxin A4 lactone analogues. RESULTS: Novel para-substituted aromatic lactone analogues of Lipoxin A4 have been synthesized in a convergent manner with six steps in the longest linear sequence in 12–13% yields, employing 2-deoxy-d-ribose as a chiral pool start...

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Autores principales: Ismael, Aya, Zeeshan, Muhammad, Hansen, Jørn H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8827294/
https://www.ncbi.nlm.nih.gov/pubmed/35139886
http://dx.doi.org/10.1186/s13104-022-05917-4
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author Ismael, Aya
Zeeshan, Muhammad
Hansen, Jørn H.
author_facet Ismael, Aya
Zeeshan, Muhammad
Hansen, Jørn H.
author_sort Ismael, Aya
collection PubMed
description OBJECTIVE: Synthesis of novel aromatic Lipoxin A4 lactone analogues. RESULTS: Novel para-substituted aromatic lactone analogues of Lipoxin A4 have been synthesized in a convergent manner with six steps in the longest linear sequence in 12–13% yields, employing 2-deoxy-d-ribose as a chiral pool starting material and the classical E-selective Wittig olefination. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13104-022-05917-4.
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spelling pubmed-88272942022-02-10 Synthesis of aromatic lactone analogues of Lipoxin A4 Ismael, Aya Zeeshan, Muhammad Hansen, Jørn H. BMC Res Notes Research Note OBJECTIVE: Synthesis of novel aromatic Lipoxin A4 lactone analogues. RESULTS: Novel para-substituted aromatic lactone analogues of Lipoxin A4 have been synthesized in a convergent manner with six steps in the longest linear sequence in 12–13% yields, employing 2-deoxy-d-ribose as a chiral pool starting material and the classical E-selective Wittig olefination. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13104-022-05917-4. BioMed Central 2022-02-09 /pmc/articles/PMC8827294/ /pubmed/35139886 http://dx.doi.org/10.1186/s13104-022-05917-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Note
Ismael, Aya
Zeeshan, Muhammad
Hansen, Jørn H.
Synthesis of aromatic lactone analogues of Lipoxin A4
title Synthesis of aromatic lactone analogues of Lipoxin A4
title_full Synthesis of aromatic lactone analogues of Lipoxin A4
title_fullStr Synthesis of aromatic lactone analogues of Lipoxin A4
title_full_unstemmed Synthesis of aromatic lactone analogues of Lipoxin A4
title_short Synthesis of aromatic lactone analogues of Lipoxin A4
title_sort synthesis of aromatic lactone analogues of lipoxin a4
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8827294/
https://www.ncbi.nlm.nih.gov/pubmed/35139886
http://dx.doi.org/10.1186/s13104-022-05917-4
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