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Effect of two oral formulations of cannabidiol on responses to emotional stimuli in healthy human volunteers: pharmaceutical vehicle matters

OBJECTIVE: To compare plasma concentrations of cannabidiol (CBD) following oral administration of two formulations of the drug (powder and dissolved in oil), and to evaluate the effects of these distinct formulations on responses to emotional stimuli in healthy human volunteers. METHODS: In a random...

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Autores principales: Crippa, José A., Pereira, Luiz C., Pereira, Lívia C., Zimmermann, Patrícia M., Brum, Liberato, Rechia, Letícia M., Dias, Isabella, Hallak, Jaime E., Campos, Alline C., Guimarães, Francisco S., Queiroz, Regina H., Zuardi, Antonio W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação Brasileira de Psiquiatria 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8827362/
https://www.ncbi.nlm.nih.gov/pubmed/34076067
http://dx.doi.org/10.1590/1516-4446-2020-1684
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author Crippa, José A.
Pereira, Luiz C.
Pereira, Lívia C.
Zimmermann, Patrícia M.
Brum, Liberato
Rechia, Letícia M.
Dias, Isabella
Hallak, Jaime E.
Campos, Alline C.
Guimarães, Francisco S.
Queiroz, Regina H.
Zuardi, Antonio W.
author_facet Crippa, José A.
Pereira, Luiz C.
Pereira, Lívia C.
Zimmermann, Patrícia M.
Brum, Liberato
Rechia, Letícia M.
Dias, Isabella
Hallak, Jaime E.
Campos, Alline C.
Guimarães, Francisco S.
Queiroz, Regina H.
Zuardi, Antonio W.
author_sort Crippa, José A.
collection PubMed
description OBJECTIVE: To compare plasma concentrations of cannabidiol (CBD) following oral administration of two formulations of the drug (powder and dissolved in oil), and to evaluate the effects of these distinct formulations on responses to emotional stimuli in healthy human volunteers. METHODS: In a randomized, double-blind, placebo-controlled, parallel-group design, 45 healthy male volunteers were randomly assigned to three groups of 15 subjects that received either 150 mg of CBD powder; 150 mg of CBD dissolved in corn oil; or placebo. Blood samples were collected at different times after administration, and a facial emotion recognition task was completed after 150 min. RESULTS: There were no significant differences across groups in the subjective and physiological measures, nor in the facial emotion recognition task. However, groups that received the drug showed statistically significant differences in baseline measures of plasma CBD, with a significantly greater difference in favor of the oil formulation. CONCLUSION: When administered as a single 150-mg dose, neither formulation of oral CBD altered responses to emotional stimuli in healthy subjects. The oil-based CBD formulation resulted in more rapid achievement of peak plasma level, with an approximate fourfold increase in oral bioavailability.
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spelling pubmed-88273622022-02-25 Effect of two oral formulations of cannabidiol on responses to emotional stimuli in healthy human volunteers: pharmaceutical vehicle matters Crippa, José A. Pereira, Luiz C. Pereira, Lívia C. Zimmermann, Patrícia M. Brum, Liberato Rechia, Letícia M. Dias, Isabella Hallak, Jaime E. Campos, Alline C. Guimarães, Francisco S. Queiroz, Regina H. Zuardi, Antonio W. Braz J Psychiatry Original Article OBJECTIVE: To compare plasma concentrations of cannabidiol (CBD) following oral administration of two formulations of the drug (powder and dissolved in oil), and to evaluate the effects of these distinct formulations on responses to emotional stimuli in healthy human volunteers. METHODS: In a randomized, double-blind, placebo-controlled, parallel-group design, 45 healthy male volunteers were randomly assigned to three groups of 15 subjects that received either 150 mg of CBD powder; 150 mg of CBD dissolved in corn oil; or placebo. Blood samples were collected at different times after administration, and a facial emotion recognition task was completed after 150 min. RESULTS: There were no significant differences across groups in the subjective and physiological measures, nor in the facial emotion recognition task. However, groups that received the drug showed statistically significant differences in baseline measures of plasma CBD, with a significantly greater difference in favor of the oil formulation. CONCLUSION: When administered as a single 150-mg dose, neither formulation of oral CBD altered responses to emotional stimuli in healthy subjects. The oil-based CBD formulation resulted in more rapid achievement of peak plasma level, with an approximate fourfold increase in oral bioavailability. Associação Brasileira de Psiquiatria 2021-05-28 /pmc/articles/PMC8827362/ /pubmed/34076067 http://dx.doi.org/10.1590/1516-4446-2020-1684 Text en https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Crippa, José A.
Pereira, Luiz C.
Pereira, Lívia C.
Zimmermann, Patrícia M.
Brum, Liberato
Rechia, Letícia M.
Dias, Isabella
Hallak, Jaime E.
Campos, Alline C.
Guimarães, Francisco S.
Queiroz, Regina H.
Zuardi, Antonio W.
Effect of two oral formulations of cannabidiol on responses to emotional stimuli in healthy human volunteers: pharmaceutical vehicle matters
title Effect of two oral formulations of cannabidiol on responses to emotional stimuli in healthy human volunteers: pharmaceutical vehicle matters
title_full Effect of two oral formulations of cannabidiol on responses to emotional stimuli in healthy human volunteers: pharmaceutical vehicle matters
title_fullStr Effect of two oral formulations of cannabidiol on responses to emotional stimuli in healthy human volunteers: pharmaceutical vehicle matters
title_full_unstemmed Effect of two oral formulations of cannabidiol on responses to emotional stimuli in healthy human volunteers: pharmaceutical vehicle matters
title_short Effect of two oral formulations of cannabidiol on responses to emotional stimuli in healthy human volunteers: pharmaceutical vehicle matters
title_sort effect of two oral formulations of cannabidiol on responses to emotional stimuli in healthy human volunteers: pharmaceutical vehicle matters
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8827362/
https://www.ncbi.nlm.nih.gov/pubmed/34076067
http://dx.doi.org/10.1590/1516-4446-2020-1684
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