Cargando…

Effect of two oral formulations of cannabidiol on responses to emotional stimuli in healthy human volunteers: pharmaceutical vehicle matters

OBJECTIVE: To compare plasma concentrations of cannabidiol (CBD) following oral administration of two formulations of the drug (powder and dissolved in oil), and to evaluate the effects of these distinct formulations on responses to emotional stimuli in healthy human volunteers. METHODS: In a random...

Descripción completa

Detalles Bibliográficos
Autores principales:	Crippa, José A., Pereira, Luiz C., Pereira, Lívia C., Zimmermann, Patrícia M., Brum, Liberato, Rechia, Letícia M., Dias, Isabella, Hallak, Jaime E., Campos, Alline C., Guimarães, Francisco S., Queiroz, Regina H., Zuardi, Antonio W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Associação Brasileira de Psiquiatria 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8827362/ https://www.ncbi.nlm.nih.gov/pubmed/34076067 http://dx.doi.org/10.1590/1516-4446-2020-1684

Ejemplares similares

Biological bases for a possible effect of cannabidiol in Parkinson’s disease
por: Ferreira-Junior, Nilson C., et al.
Publicado: (2019)

Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age
por: Crippa, José A., et al.
Publicado: (2018)

Δ9-THC Intoxication by Cannabidiol-Enriched Cannabis Extract in Two Children with Refractory Epilepsy: Full Remission after Switching to Purified Cannabidiol
por: Crippa, José A. S., et al.
Publicado: (2016)

The anxiolytic effect of cannabidiol depends on the nature of the trauma when patients with post-traumatic stress disorder recall their trigger event
por: Bolsoni, Lívia Maria, et al.
Publicado: (2022)

Cannabidiol presents an inverted U-shaped dose-response curve in a simulated public speaking test
por: Linares, Ila M., et al.
Publicado: (2018)

No Acute Effects of Cannabidiol on the Sleep-Wake Cycle of Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study
por: Linares, Ila M. P., et al.
Publicado: (2018)

Case Report: Cannabidiol-Induced Skin Rash: A Case Series and Key Recommendations
por: Souza, José Diogo S., et al.
Publicado: (2022)

17.4 POSSIBLE MECHANISMS INVOLVED IN THE ANTIPSYCHOTIC EFFECTS OF CANNABIDIOL (CBD)
por: Crippa, Jose Alexandre, et al.
Publicado: (2018)

Inverted U-Shaped Dose-Response Curve of the Anxiolytic Effect of Cannabidiol during Public Speaking in Real Life
por: Zuardi, Antonio W., et al.
Publicado: (2017)

Evaluation of Serum Cytokines Levels and the Role of Cannabidiol Treatment in Animal Model of Asthma
por: Vuolo, Francieli, et al.
Publicado: (2015)

Cannabidiol, among Other Cannabinoid Drugs, Modulates Prepulse Inhibition of Startle in the SHR Animal Model: Implications for Schizophrenia Pharmacotherapy
por: Peres, Fernanda F., et al.
Publicado: (2016)

Cannabidiol induces autophagy via ERK1/2 activation in neural cells
por: Vrechi, Talita A. M., et al.
Publicado: (2021)

Adverse Effects of Oral Cannabidiol: An Updated Systematic Review of Randomized Controlled Trials (2020–2022)
por: Souza, José Diogo R., et al.
Publicado: (2022)

Cannabidiol for the treatment of crack-cocaine craving: an exploratory double-blind study
por: de Meneses-Gaya, Carolina, et al.
Publicado: (2020)

Fluorinated Cannabidiol Derivatives: Enhancement of Activity in Mice Models Predictive of Anxiolytic, Antidepressant and Antipsychotic Effects
por: Breuer, Aviva, et al.
Publicado: (2016)

A Conversion of Oral Cannabidiol to Delta9-Tetrahydrocannabinol Seems Not to Occur in Humans
por: Nahler, Gerhard, et al.
Publicado: (2017)

Cannabidiol Administered During Peri-Adolescence Prevents Behavioral Abnormalities in an Animal Model of Schizophrenia
por: Peres, Fernanda F., et al.
Publicado: (2018)

Evaluation of the role of the cannabidiol system in an animal model of ischemia/reperfusion kidney injury
por: Soares, Rodrigo Zon, et al.
Publicado: (2015)

Dr. Raphael Mechoulam, cannabis and cannabinoids research pioneer (November 5, 1930–March 9, 2023) and his legacy for Brazilian pharmacology
por: Crippa, José Alexandre S., et al.
Publicado: (2023)

Correction: Fluorinated Cannabidiol Derivatives: Enhancement of Activity in Mice Models Predictive of Anxiolytic, Antidepressant and Antipsychotic Effects
por: Breuer, Aviva, et al.
Publicado: (2016)

Is Cannabidiol During Neurodevelopment a Promising Therapy for Schizophrenia and Autism Spectrum Disorders?
por: Loss, Cássio Morais, et al.
Publicado: (2021)

Antiapoptotic effects of cannabidiol in an experimental model of cognitive decline induced by brain iron overload
por: da Silva, Vanessa Kappel, et al.
Publicado: (2018)

Maintained anxiolytic effects of cannabidiol after treatment discontinuation in healthcare workers during the COVID-19 pandemic
por: Souza, José Diogo S., et al.
Publicado: (2022)

Cannabidiol Prevents Motor and Cognitive Impairments Induced by Reserpine in Rats
por: Peres, Fernanda F., et al.
Publicado: (2016)

Maternal administration of cannabidiol promotes an anti-inflammatory effect on the intestinal wall in a gastroschisis rat model
por: Callejas, G.H., et al.
Publicado: (2018)

Evidences for the Anti-panic Actions of Cannabidiol
por: Soares, Vanessa P., et al.
Publicado: (2017)

Systemic Chronic Treatment with Cannabidiol in Carioca High- and Low-Conditioned Freezing Rats in the Neuropathic Pain Model: Evaluation of Pain Sensitivity
por: Macêdo-Souza, Carolina, et al.
Publicado: (2023)

Cannabidiol as a Promising Strategy to Treat and Prevent Movement Disorders?
por: Peres, Fernanda F., et al.
Publicado: (2018)

Marijuana, feijoada and the debate on drug legalization
por: Crippa, José A. S., et al.
Publicado: (2013)

Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13
por: Falvella, Ana Caroline Brambilla, et al.
Publicado: (2021)

Glial Cells and Their Contribution to the Mechanisms of Action of Cannabidiol in Neuropsychiatric Disorders
por: Scarante, Franciele F., et al.
Publicado: (2021)

Corrigendum: Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13
por: Falvella, Ana Caroline Brambilla, et al.
Publicado: (2021)

Cannabidiol Is a Potential Therapeutic for the Affective-Motivational Dimension of Incision Pain in Rats
por: Genaro, Karina, et al.
Publicado: (2017)

Protective Effects of Cannabidiol against Seizures and Neuronal Death in a Rat Model of Mesial Temporal Lobe Epilepsy
por: Do Val-da Silva, Raquel A., et al.
Publicado: (2017)

Sex-dependent differences in the anxiolytic-like effect of cannabidiol in the elevated plus-maze
por: Fabris, Débora, et al.
Publicado: (2022)

Monitoring the Mental Health and Professional Overload of Health Workers in Brazil: A Longitudinal Study Considering the First Wave of the COVID-19 Pandemic
por: Osório, Flávia L., et al.
Publicado: (2022)

Mucosal Delivery of Cannabidiol: Influence of Vehicles and Enhancers
por: Tabboon, Peera, et al.
Publicado: (2022)

Workplace Protections and Burnout Among Brazilian Frontline Health Care Professionals During the COVID-19 Pandemic
por: Pereira-Lima, Karina, et al.
Publicado: (2022)

Efficacy and Safety of Cannabidiol Plus Standard Care vs Standard Care Alone for the Treatment of Emotional Exhaustion and Burnout Among Frontline Health Care Workers During the COVID-19 Pandemic: A Randomized Clinical Trial
por: Crippa, José Alexandre S., et al.
Publicado: (2021)

Risk and Protective Factors for the Mental Health of Brazilian Healthcare Workers in the Frontline of COVID-19 Pandemic
por: Osório, Flávia L., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_f38i8mc2fgjgfnlhqs9fi3992s