Hypoxia-Inducible Factor-1α (HIF-1α) Inhibition Impairs Retinoic Acid-Induced Differentiation in SH-SY5Y Neuroblastoma Cells, Leading to Reduced Neurite Length and Diminished Gene Expression Related to Cell Differentiation

Neuroblastoma is the most common extracranial solid tumour in childhood, originated from cells of the neural crest during the development of the Sympathetic Nervous System. Retinoids are vitamin-A derived differentiating agents utilised to avoid disease resurgence in high-risk neuroblastoma treatmen...

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Detalles Bibliográficos
Autores principales: Brum, Pedro Ozorio, Viola, Guilherme Danielski, Saibro-Girardi, Carolina, Tiefensee-Ribeiro, Camila, Brum, Matheus Ozorio, Gasparotto, Juciano, Krolow, Rachel, Moreira, José Cláudio Fonseca, Gelain, Daniel Pens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8827409/
https://www.ncbi.nlm.nih.gov/pubmed/34557995
http://dx.doi.org/10.1007/s11064-021-03454-3

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