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Optimizing environmental safety and cell-killing potential of oncolytic Newcastle Disease virus with modifications of the V, F and HN genes

Newcastle Disease Virus (NDV) is an avian RNA virus, which was shown to be effective and safe for use in oncolytic viral therapy for several tumour malignancies. The presence of a multi basic cleavage site (MBCS) in the fusion protein improved its oncolytic efficacy in vitro and in vivo. However, ND...

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Detalles Bibliográficos
Autores principales:	de Graaf, J. Fréderique, van Nieuwkoop, Stefan, Bestebroer, Theo, Groeneveld, Daphne, van Eijck, Casper H. J., Fouchier, Ron A. M., van den Hoogen, Bernadette G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8827430/ https://www.ncbi.nlm.nih.gov/pubmed/35139115 http://dx.doi.org/10.1371/journal.pone.0263707

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