Cargando…

Efficacy of Use of Triamcinolone Ointment for Clean Intermittent Self Catheterization following Internal Urethrotomy

INTRODUCTION: Internal urethrotomy is recommended for the treatment of urethral strictures shorter than 1.5 cm but has been associated with high recurrence rates. The aim of this study was to evaluate the efficacy of use of triamcinolone ointment for clean intermittent self catheterization in the pr...

Descripción completa

Detalles Bibliográficos
Autores principales: Regmi, Sunil, Adhikari, Sunil Chandra, Yadav, Saroj, Singh, Rabin Raj, Bastakoti, Ravi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Journal of the Nepal Medical Association 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8827553/
https://www.ncbi.nlm.nih.gov/pubmed/30387461
http://dx.doi.org/10.31729/jnma.3704
_version_ 1784647655831371776
author Regmi, Sunil
Adhikari, Sunil Chandra
Yadav, Saroj
Singh, Rabin Raj
Bastakoti, Ravi
author_facet Regmi, Sunil
Adhikari, Sunil Chandra
Yadav, Saroj
Singh, Rabin Raj
Bastakoti, Ravi
author_sort Regmi, Sunil
collection PubMed
description INTRODUCTION: Internal urethrotomy is recommended for the treatment of urethral strictures shorter than 1.5 cm but has been associated with high recurrence rates. The aim of this study was to evaluate the efficacy of use of triamcinolone ointment for clean intermittent self catheterization in the prevention of urethral stricture recurrence after internal urethrotomy. METHODS: Total of 60 male patients undergoing internal urethrotomy were assigned into two groups and clean intermittent self catheterization was performed using either triamcinolone ointment or a water-based gel for lubrication of the catheter in this randomized clinical trial. Clean intermittent self catheterization regimen was continued for 6 months and patients were followed for 12 months. Urethrocystoscopic evaluation was done 6 and 12 months postoperatively. RESULTS: The recurrence rates were compared between the two groups. There were no significant differences in patient characteristics and etiology of the stricture between the two groups. There was a 6 (22.22%) recurrence rate in the patients of the triamcinolone group against 13 (46.42%) in those of the control group after the first internal urethrotomy (P=0.04). After second internal urethrotomy, the urethra was stabilized in 5 (83.3%) of the patients in the triamcinolone group and 8 (61.5%) those in the control group (P=0.05). We also found a significant correlation between recurrence and stricture length (P=0.02) but the time to recurrence was not statistically significant (P=0.16). CONCLUSIONS: The use of triamcinolone ointment in patients on CISC regimen after internal urethrotomy significantly decreased the stricture recurrence rate.
format Online
Article
Text
id pubmed-8827553
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Journal of the Nepal Medical Association
record_format MEDLINE/PubMed
spelling pubmed-88275532022-02-25 Efficacy of Use of Triamcinolone Ointment for Clean Intermittent Self Catheterization following Internal Urethrotomy Regmi, Sunil Adhikari, Sunil Chandra Yadav, Saroj Singh, Rabin Raj Bastakoti, Ravi JNMA J Nepal Med Assoc Original Article INTRODUCTION: Internal urethrotomy is recommended for the treatment of urethral strictures shorter than 1.5 cm but has been associated with high recurrence rates. The aim of this study was to evaluate the efficacy of use of triamcinolone ointment for clean intermittent self catheterization in the prevention of urethral stricture recurrence after internal urethrotomy. METHODS: Total of 60 male patients undergoing internal urethrotomy were assigned into two groups and clean intermittent self catheterization was performed using either triamcinolone ointment or a water-based gel for lubrication of the catheter in this randomized clinical trial. Clean intermittent self catheterization regimen was continued for 6 months and patients were followed for 12 months. Urethrocystoscopic evaluation was done 6 and 12 months postoperatively. RESULTS: The recurrence rates were compared between the two groups. There were no significant differences in patient characteristics and etiology of the stricture between the two groups. There was a 6 (22.22%) recurrence rate in the patients of the triamcinolone group against 13 (46.42%) in those of the control group after the first internal urethrotomy (P=0.04). After second internal urethrotomy, the urethra was stabilized in 5 (83.3%) of the patients in the triamcinolone group and 8 (61.5%) those in the control group (P=0.05). We also found a significant correlation between recurrence and stricture length (P=0.02) but the time to recurrence was not statistically significant (P=0.16). CONCLUSIONS: The use of triamcinolone ointment in patients on CISC regimen after internal urethrotomy significantly decreased the stricture recurrence rate. Journal of the Nepal Medical Association 2018 2018-08-31 /pmc/articles/PMC8827553/ /pubmed/30387461 http://dx.doi.org/10.31729/jnma.3704 Text en © The Author(s) 2018. https://creativecommons.org/licenses/by/4.0/This is an Open-Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Regmi, Sunil
Adhikari, Sunil Chandra
Yadav, Saroj
Singh, Rabin Raj
Bastakoti, Ravi
Efficacy of Use of Triamcinolone Ointment for Clean Intermittent Self Catheterization following Internal Urethrotomy
title Efficacy of Use of Triamcinolone Ointment for Clean Intermittent Self Catheterization following Internal Urethrotomy
title_full Efficacy of Use of Triamcinolone Ointment for Clean Intermittent Self Catheterization following Internal Urethrotomy
title_fullStr Efficacy of Use of Triamcinolone Ointment for Clean Intermittent Self Catheterization following Internal Urethrotomy
title_full_unstemmed Efficacy of Use of Triamcinolone Ointment for Clean Intermittent Self Catheterization following Internal Urethrotomy
title_short Efficacy of Use of Triamcinolone Ointment for Clean Intermittent Self Catheterization following Internal Urethrotomy
title_sort efficacy of use of triamcinolone ointment for clean intermittent self catheterization following internal urethrotomy
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8827553/
https://www.ncbi.nlm.nih.gov/pubmed/30387461
http://dx.doi.org/10.31729/jnma.3704
work_keys_str_mv AT regmisunil efficacyofuseoftriamcinoloneointmentforcleanintermittentselfcatheterizationfollowinginternalurethrotomy
AT adhikarisunilchandra efficacyofuseoftriamcinoloneointmentforcleanintermittentselfcatheterizationfollowinginternalurethrotomy
AT yadavsaroj efficacyofuseoftriamcinoloneointmentforcleanintermittentselfcatheterizationfollowinginternalurethrotomy
AT singhrabinraj efficacyofuseoftriamcinoloneointmentforcleanintermittentselfcatheterizationfollowinginternalurethrotomy
AT bastakotiravi efficacyofuseoftriamcinoloneointmentforcleanintermittentselfcatheterizationfollowinginternalurethrotomy