A functional genomic approach to actionable gene fusions for precision oncology

Fusion genes represent a class of attractive therapeutic targets. Thousands of fusion genes have been identified in patients with cancer, but the functional consequences and therapeutic implications of most of these remain largely unknown. Here, we develop a functional genomic approach that consists...

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Detalles Bibliográficos
Autores principales: Li, Jun, Lu, Hengyu, Ng, Patrick Kwok-Shing, Pantazi, Angeliki, Ip, Carman Ka Man, Jeong, Kang Jin, Amador, Bianca, Tran, Richard, Tsang, Yiu Huen, Yang, Lixing, Song, Xingzhi, Dogruluk, Turgut, Ren, Xiaojia, Hadjipanayis, Angela, Bristow, Christopher A., Lee, Semin, Kucherlapati, Melanie, Parfenov, Michael, Tang, Jiabin, Seth, Sahil, Mahadeshwar, Harshad S., Mojumdar, Kamalika, Zeng, Dong, Zhang, Jianhua, Protopopov, Alexei, Seidman, Jonathan G., Creighton, Chad J., Lu, Yiling, Sahni, Nidhi, Shaw, Kenna R., Meric-Bernstam, Funda, Futreal, Andrew, Chin, Lynda, Scott, Kenneth L., Kucherlapati, Raju, Mills, Gordon B., Liang, Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8827659/
https://www.ncbi.nlm.nih.gov/pubmed/35138907
http://dx.doi.org/10.1126/sciadv.abm2382

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