Screening of ETO2-GLIS2–induced Super Enhancers identifies targetable cooperative dependencies in acute megakaryoblastic leukemia

Super Enhancers (SEs) are clusters of regulatory elements associated with cell identity and disease. However, whether these elements are induced by oncogenes and can regulate gene modules cooperating for cancer cell transformation or maintenance remains elusive. To address this question, we conducte...

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Detalles Bibliográficos
Autores principales: Benbarche, Salima, Lopez, Cécile K., Salataj, Eralda, Aid, Zakia, Thirant, Cécile, Laiguillon, Marie-Charlotte, Lecourt, Séverine, Belloucif, Yannis, Vaganay, Camille, Antonini, Marion, Hu, Jiang, da Silva Babinet, Alexandra, Ndiaye-Lobry, Delphine, Pardieu, Bryann, Petit, Arnaud, Puissant, Alexandre, Chaumeil, Julie, Mercher, Thomas, Lobry, Camille
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8827662/
https://www.ncbi.nlm.nih.gov/pubmed/35138899
http://dx.doi.org/10.1126/sciadv.abg9455

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