73565 Defining tp53 tumor suppressor functions in zebrafish embryonal rhabdomyosarcoma

ABSTRACT IMPACT: By assessing function of mutant (patient-specific) tp53 in zebrafish embryonal rhabdomyosarcoma will inform clinicians of the severity of mutant tp53 alleles. OBJECTIVES/GOALS: This study aims to define loss- and gain-of-function TP53 mutations by comparing effects in tp53-null and...

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Autores principales: Baxi, Kunal, Chen, Jiangfei, Lipsitt, Amanda, Hensch, Nicole, Wang, Long, Bandopadhyay, Abhik, Sugalski, Aaron, Gilbert, Andrea, Chen, Eleanor, Houghton, Peter, Tomlinson, Gail, Ignatius, Myron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2021
Materias:
Basic Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8827740/
http://dx.doi.org/10.1017/cts.2021.454

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