Cargando…

13109 Phosphorylation state of Myristoylated Alanine-Rich C-Kinase Substrate Effector Domain mimetics determines its cytotoxicity in glioblastoma and macrophage model

ABSTRACT IMPACT: This study provides insight into how MED2 impacts the immune cells surrounding glioblastoma that help it to grow and spread; having a more complete understanding of how MED2 works will help us better develop therapies that may one day enter the clinic to improve patient outcomes in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Alrefai, Hasan, Eustace, Nicholas J., Anderson, Joshua C., Hicks, Patricia H., King, Peter H., Willey, Christopher D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cambridge University Press 2021
Materias:	Basic Science
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8827758/ http://dx.doi.org/10.1017/cts.2021.403

Ejemplares similares

Myristoylated alanine-rich C-kinase substrate effector domain phosphorylation regulates the growth and radiation sensitization of glioblastoma
por: Eustace, Nicholas J., et al.
Publicado: (2019)

Fibroblast Migration Is Regulated by Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Protein
por: Ott, Laura E., et al.
Publicado: (2013)

Prognostic Value of Upregulation of Myristoylated Alanine-Rich C-Kinase Substrate in Gastric Cancer
por: Quan, Ruiliang, et al.
Publicado: (2019)

Pathophysiological roles of myristoylated alanine-rich C-kinase substrate (MARCKS) in hematological malignancies
por: Iyer, Deepak Narayanan, et al.
Publicado: (2021)

Small Organic Compounds Mimicking the Effector Domain of Myristoylated Alanine-Rich C-Kinase Substrate Stimulate Female-Specific Neurite Outgrowth
por: Tschang, Monica, et al.
Publicado: (2023)

X MARCKS the spot: myristoylated alanine-rich C kinase substrate in neuronal function and disease
por: Brudvig, Jon J., et al.
Publicado: (2015)

Myristoylated, alanine-rich C-kinase substrate (MARCKS) regulates toll-like receptor 4 signaling in macrophages
por: Issara-Amphorn, Jiraphorn, et al.
Publicado: (2023)

A cell-penetrating MARCKS mimetic selectively triggers cytolytic death in glioblastoma
por: Eustace, Nicholas J., et al.
Publicado: (2020)

Myristoylated, Alanine-rich C-kinase Substrate (MARCKS) regulates Toll-like receptor 4 signaling in macrophages
por: Issara-Amphorn, Jiraphorn, et al.
Publicado: (2023)

MARCKS phosphorylation is modulated by a peptide mimetic of MARCKS effector domain leading to increased radiation sensitivity in lung cancer cell lines
por: Rohrbach, Timothy D., et al.
Publicado: (2017)

Activation of protein kinase C results in the displacement of its myristoylated, alanine-rich substrate from punctate structures in macrophage filopodia
Publicado: (1990)

Dysbindin Regulates the Transcriptional Level of Myristoylated Alanine-Rich Protein Kinase C Substrate via the Interaction with NF-YB in Mice Brain
por: Okuda, Hiroaki, et al.
Publicado: (2010)

A myristoylated alanine-rich C-kinase substrate (MARCKS) inhibitor peptide attenuates neutrophil outside-in β(2)-integrin activation and signaling
por: Conley, Haleigh, et al.
Publicado: (2023)

Retraction for Cortical F-Actin, the Exocytic Mode, and Neuropeptide Release in Mouse Chromaffin Cells Is Regulated by Myristoylated Alanine-rich C-Kinase Substrate and Myosin II
Publicado: (2013)

Investigation of partially myristoylated carboxymethyl chitosan, an amphoteric‐amphiphilic chitosan derivative, as a new material for cosmetic and dermal application
por: Seino, Haruyoshi, et al.
Publicado: (2020)

Myristoylated Alanine‐Rich Protein Kinase Substrate (MARCKS) Regulates Small GTPase Rac1 and Cdc42 Activity and Is a Critical Mediator of Vascular Smooth Muscle Cell Migration in Intimal Hyperplasia Formation
por: Yu, Dan, et al.
Publicado: (2015)

Myristoylation versus SRP
por: LeBrasseur, Nicole
Publicado: (2005)

Data on the calcium-induced mobility shift of myristoylated and non-myristoylated forms of neurocalcin delta
por: Viviano, Jeffrey, et al.
Publicado: (2016)

MYRbase: analysis of genome-wide glycine myristoylation enlarges the functional spectrum of eukaryotic myristoylated proteins
por: Maurer-Stroh, Sebastian, et al.
Publicado: (2004)

Profiling of myristoylation in Toxoplasma gondii reveals an N-myristoylated protein important for host cell penetration
por: Broncel, Malgorzata, et al.
Publicado: (2020)

Design and Characterization of Myristoylated and Non-Myristoylated Peptides Effective against Candida spp. Clinical Isolates
por: Bugli, Francesca, et al.
Publicado: (2022)

Insulin-mimetic compound hexaquis (benzylammonium) decavanadate is antilipolytic in human fat cells
por: Carpéné, Christian, et al.
Publicado: (2017)

Myristoylation profiling in human cells and zebrafish
por: Broncel, Malgorzata, et al.
Publicado: (2015)

Protein Lipidation by Palmitoylation and Myristoylation in Cancer
por: Fhu, Chee Wai, et al.
Publicado: (2021)

Cytotoxicity of the effector protein BteA was attenuated in Bordetella pertussis by insertion of an alanine residue
por: Bayram, Jan, et al.
Publicado: (2020)

FRK inhibits glioblastoma progression via phosphorylating YAP and inducing its ubiquitylation and degradation by Siah1
por: Wang, Yan, et al.
Publicado: (2022)

Spatiotemporal Regulation of FMNL2 by N-Terminal Myristoylation and C-Terminal Phosphorylation Drives Rapid Filopodia Formation
por: Lorenzen, Lina, et al.
Publicado: (2023)

P465: N-MYRISTOYLATION INHIBITION ABROGATES OXIDATIVE PHOSPHORYLATION TO TARGET ACUTE MYELOID LEUKEMIA STEM CELLS
por: Gamma, Jay, et al.
Publicado: (2023)

Prediction of N-myristoylation modification of proteins by SVM
por: Cao, Wei, et al.
Publicado: (2011)

Targeting protein myristoylation for the treatment of prostate cancer
por: Sulejmani, Essilvo, et al.
Publicado: (2018)

Myristoylation: An Important Protein Modification in the Immune Response
por: Udenwobele, Daniel Ikenna, et al.
Publicado: (2017)

Thrombospondin-1 mimetics are promising novel therapeutics for MYC-associated medulloblastoma
por: Chan, Tiffany S Y, et al.
Publicado: (2021)

Mitochondrial Substrate-Level Phosphorylation as Energy Source for Glioblastoma: Review and Hypothesis
por: Chinopoulos, Christos, et al.
Publicado: (2018)

The Sea as a Rich Source of Structurally Unique Glycosaminoglycans and Mimetics
por: Vasconcelos, Ariana A., et al.
Publicado: (2017)

Myristoylated CIL-7 regulates ciliary extracellular vesicle biogenesis
por: Maguire, Julie E., et al.
Publicado: (2015)

Predicting N-terminal myristoylation sites in plant proteins
por: Podell, Sheila, et al.
Publicado: (2004)

Data on the identity and myristoylation state of recombinant, purified hippocalcin
por: Krishnan, Anuradha, et al.
Publicado: (2016)

Targeting N-myristoylation for therapy of B-cell lymphomas
por: Beauchamp, Erwan, et al.
Publicado: (2020)

N-myristoylation: from cell biology to translational medicine
por: Yuan, Meng, et al.
Publicado: (2020)

Encapsulating Cas9 into extracellular vesicles by protein myristoylation
por: Whitley, Joseph Andrew, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_f716v8c7fc7g139o3oiii0bbtt