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32329 A novel mouse model of Ataxia Telangiectasia for testing small molecule readthrough compounds

ABSTRACT IMPACT: Small molecule readthrough compounds are a promising therapeutic with the potential to overcome nonsense mutations thereby enabling the production of functional ATM protein in patients with Ataxia Telangiectasia OBJECTIVES/GOALS: To generate a novel mouse model of Ataxia-Telangiecta...

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Detalles Bibliográficos
Autor principal:	Mathews, Paul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cambridge University Press 2021
Materias:	Basic Science
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8827764/ http://dx.doi.org/10.1017/cts.2021.430

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