Cargando…
15727 K(ATP) channel prodrugs as therapeutics for chronic pain and substance abuse disorders
ABSTRACT IMPACT: Pharmacological activation of K(ATP) channels may provide analgesia and attenuate opioid tolerance and withdrawal OBJECTIVES/GOALS: Our long term goal is to develop therapeutics for the treatment of the overuse of opioids. The objective of this application is to test novel K(ATP) ch...
Autores principales: | Doucette, Alexis, Johnson, Kayla, Dosa, Peter I., Klein, Amanda H |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cambridge University Press
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8827765/ http://dx.doi.org/10.1017/cts.2021.422 |
Ejemplares similares
-
Morphine Efficacy, Tolerance, and Hypersensitivity Are Altered After Modulation of SUR1 Subtype K(ATP) Channel Activity in Mice
por: Fisher, Cole, et al.
Publicado: (2019) -
Ocular Hypotensive Properties and Biochemical Profile of QLS-101, a Novel ATP-Sensitive Potassium (K(ATP)) Channel Opening Prodrug
por: Pervan-Steel, Cynthia L., et al.
Publicado: (2022) -
Localization of ATP-sensitive K(+) channel subunits in rat liver
por: Zhou, Ming, et al.
Publicado: (2019) -
An experimental investigation of a novel iron chelating protoporphyrin IX prodrug for the enhancement of photodynamic therapy
por: Anayo, Lizette, et al.
Publicado: (2018) -
How ATP Inhibits the Open K(ATP) Channel
por: Craig, Tim J., et al.
Publicado: (2008)