48218 Preclinical modeling of BRAF(V600E)/PTEN-/- melanoma leptomeningeal disease (LMD) to assess intrathecal checkpoint blockade

1. Develop an immunocompetent murine model of melanoma LMD with tumors bearing genetic mutations commonly found in patients, specifically BRAF(V600E)/PTEN-/-. 2. Assess the safety of intrathecal (IT) immunotherapy, specifically anti-PD1 antibody (aPD1). 3. Evaluate the therapeutic efficacy of IT aPD...

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Detalles Bibliográficos
Autores principales: Guerrieri, Renato A., Fischer, Grant M., Knighton, Barbara G., Hudgens, Courtney W., Ledesma, Debora A., Davies, Michael A., Ferguson, Sherise D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2021
Materias:
Mechanistic Basic to Clinical
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8827802/
http://dx.doi.org/10.1017/cts.2021.629

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8827802/
http://dx.doi.org/10.1017/cts.2021.629

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