79696 Reversible DNA Hypermethylation of the Interleukin-15 Promoter Induces IL-15 Expression, Drives the Pathogenesis of T-Cell Large Granular Lymphocytic Leukemia (T-LGLL) and Provides a Therapeutic Approach Using 5-Azacitidine

ABSTRACT IMPACT: This work describes, for the first time, the methylome in patients with T-LGLL, focusing on the IL-15 promoter, and clearly demonstrates that 5-azacytidine decreases IL-15 production leading to T-LGLL cell death. These results form the basis a translational clinical trial in T-LGLL...

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Detalles Bibliográficos
Autores principales: Brammer, Jonathan E, Mishra, Anjali, Boles, Amy, Mansour, Anthony, Mathe-Allainmat, Monique, Quemener, Agnes, Porcu, Pierluigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2021
Materias:
Mechanistic Basic to Clinical
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8827996/
http://dx.doi.org/10.1017/cts.2021.638

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