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Covalent inhibition of endoplasmic reticulum chaperone GRP78 disconnects the transduction of ER stress signals to inflammation and lipid accumulation in diet-induced obese mice

Targeting endoplasmic reticulum (ER) stress, inflammation, and metabolic dysfunctions may halt the pathogenesis of obesity and thereby reduce the prevalence of diabetes, cardiovascular disesases, and cancers. The present study was designed to elucidate the mechnaisms by which plant-derived celastrol...

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Detalles Bibliográficos
Autores principales:	Luo, Dan, Fan, Ni, Zhang, Xiuying, Ngo, Fung Yin, Zhao, Jia, Zhao, Wei, Huang, Ming, Li, Ding, Wang, Yu, Rong, Jianhui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2022
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828050/ https://www.ncbi.nlm.nih.gov/pubmed/35138251 http://dx.doi.org/10.7554/eLife.72182

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