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A helicase-tethered ORC flip enables bidirectional helicase loading

Replication origins are licensed by loading two Mcm2-7 helicases around DNA in a head-to-head conformation poised to initiate bidirectional replication. This process requires origin–recognition complex (ORC), Cdc6, and Cdt1. Although different Cdc6 and Cdt1 molecules load each helicase, whether two...

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Detalles Bibliográficos
Autores principales:	Gupta, Shalini, Friedman, Larry J, Gelles, Jeff, Bell, Stephen P
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828053/ https://www.ncbi.nlm.nih.gov/pubmed/34882090 http://dx.doi.org/10.7554/eLife.74282

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