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Successful endoscopic diagnosis of angiosarcoma of the small intestine: A case report
A 51‐year‐old man had hematochezia, anemia, and an intraabdominal mass. Gastroscopy and colonoscopy showed no significant lesions with intraluminal bleeding, while radiological examinations showed bulky swelling of the lymph nodes around the abdominal aorta and a tumor in the left ischial bone. Smal...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828187/ https://www.ncbi.nlm.nih.gov/pubmed/35310717 http://dx.doi.org/10.1002/deo2.24 |
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author | Tamura, Koichi Matsuda, Kenji Ito, Daisaku Sakanaka, Toshihiro Tamiya, Masato Hyo, Takahiko Kitano, Masayuki Yamaue, Hiroki |
author_facet | Tamura, Koichi Matsuda, Kenji Ito, Daisaku Sakanaka, Toshihiro Tamiya, Masato Hyo, Takahiko Kitano, Masayuki Yamaue, Hiroki |
author_sort | Tamura, Koichi |
collection | PubMed |
description | A 51‐year‐old man had hematochezia, anemia, and an intraabdominal mass. Gastroscopy and colonoscopy showed no significant lesions with intraluminal bleeding, while radiological examinations showed bulky swelling of the lymph nodes around the abdominal aorta and a tumor in the left ischial bone. Small intestine endoscopy detected a dark purpuric protruding tumor of the jejunum and its biopsy specimen brought a definitive diagnosis of primary jejunal epithelioid angiosarcoma from positive staining of AE1/AE3, CD31, and erythroblast transformation specific related gene in immunohistochemical studies. The patient underwent surgical resection with adjuvant chemotherapy but died of progression of metastases 7 months after the diagnosis. Epithelioid angiosarcoma of the gastrointestinal tract is an extremely rare malignancy with poor prognosis and it is challenging to distinguish from undifferentiated carcinoma or melanoma. Immunohistochemistry is necessary for a definitive diagnosis. Sufficient biopsy specimen may aid a prompt diagnosis of this disease of the small intestine, which may present as obscure gastrointestinal bleeding. |
format | Online Article Text |
id | pubmed-8828187 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88281872022-03-17 Successful endoscopic diagnosis of angiosarcoma of the small intestine: A case report Tamura, Koichi Matsuda, Kenji Ito, Daisaku Sakanaka, Toshihiro Tamiya, Masato Hyo, Takahiko Kitano, Masayuki Yamaue, Hiroki DEN Open Original Articles A 51‐year‐old man had hematochezia, anemia, and an intraabdominal mass. Gastroscopy and colonoscopy showed no significant lesions with intraluminal bleeding, while radiological examinations showed bulky swelling of the lymph nodes around the abdominal aorta and a tumor in the left ischial bone. Small intestine endoscopy detected a dark purpuric protruding tumor of the jejunum and its biopsy specimen brought a definitive diagnosis of primary jejunal epithelioid angiosarcoma from positive staining of AE1/AE3, CD31, and erythroblast transformation specific related gene in immunohistochemical studies. The patient underwent surgical resection with adjuvant chemotherapy but died of progression of metastases 7 months after the diagnosis. Epithelioid angiosarcoma of the gastrointestinal tract is an extremely rare malignancy with poor prognosis and it is challenging to distinguish from undifferentiated carcinoma or melanoma. Immunohistochemistry is necessary for a definitive diagnosis. Sufficient biopsy specimen may aid a prompt diagnosis of this disease of the small intestine, which may present as obscure gastrointestinal bleeding. John Wiley and Sons Inc. 2021-08-22 /pmc/articles/PMC8828187/ /pubmed/35310717 http://dx.doi.org/10.1002/deo2.24 Text en © 2021 The Authors. DEN Open published by John Wiley & Sons Australia, Ltd on behalf of Japan Gastroenterological Endoscopy Society https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Tamura, Koichi Matsuda, Kenji Ito, Daisaku Sakanaka, Toshihiro Tamiya, Masato Hyo, Takahiko Kitano, Masayuki Yamaue, Hiroki Successful endoscopic diagnosis of angiosarcoma of the small intestine: A case report |
title | Successful endoscopic diagnosis of angiosarcoma of the small intestine: A case report |
title_full | Successful endoscopic diagnosis of angiosarcoma of the small intestine: A case report |
title_fullStr | Successful endoscopic diagnosis of angiosarcoma of the small intestine: A case report |
title_full_unstemmed | Successful endoscopic diagnosis of angiosarcoma of the small intestine: A case report |
title_short | Successful endoscopic diagnosis of angiosarcoma of the small intestine: A case report |
title_sort | successful endoscopic diagnosis of angiosarcoma of the small intestine: a case report |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828187/ https://www.ncbi.nlm.nih.gov/pubmed/35310717 http://dx.doi.org/10.1002/deo2.24 |
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