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Endoscopic and pathologic motifs for the clinical diagnosis of Epstein–Barr virus‐associated gastric cancer

OBJECTIVES: Based on the recent therapeutic trends for gastric cancer (GC), the clinical impact of the diagnosis of Epstein–Barr virus (EBV)‐associated GC (EBVaGC) appears to be important. We retrospectively analyzed endoscopic and pathologic motifs of GC lesions to narrow the number of candidates f...

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Autores principales: Yanai, Hideo, Chihara, Daisuke, Harano, Megumi, Sakaguchi, Eiki, Murakami, Tomoyuki, Nishikawa, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828195/
https://www.ncbi.nlm.nih.gov/pubmed/35310151
http://dx.doi.org/10.1002/deo2.7
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author Yanai, Hideo
Chihara, Daisuke
Harano, Megumi
Sakaguchi, Eiki
Murakami, Tomoyuki
Nishikawa, Jun
author_facet Yanai, Hideo
Chihara, Daisuke
Harano, Megumi
Sakaguchi, Eiki
Murakami, Tomoyuki
Nishikawa, Jun
author_sort Yanai, Hideo
collection PubMed
description OBJECTIVES: Based on the recent therapeutic trends for gastric cancer (GC), the clinical impact of the diagnosis of Epstein–Barr virus (EBV)‐associated GC (EBVaGC) appears to be important. We retrospectively analyzed endoscopic and pathologic motifs of GC lesions to narrow the number of candidates for EBV testing. METHODS: We performed EBV tests for 32 upper gastrointestinal lesions of 32 patients in the clinical setting. These tests were ordered by endoscopists or by pathologists without an endoscopist's order. EBV‐encoded small RNA1 (EBER1) in situ hybridization was used for the EBV tests. The endoscopic motif for the EBV test was the location in the upper part of the stomach or remnant stomach, mainly the depressed type with a submucosal tumor‐like protrusion of the lesion. The pathologic motif was carcinoma with lymphoid stroma (CLS) or CLS‐like histology of the lesion. We retrospectively analyzed the results of EBV tests for the endoscopic and pathologic motifs. RESULTS: The final pathological diagnoses of the 32 subjects were 26 GCs including CLS, gastric endocrine cell carcinoma, gastric hepatoid carcinoma, gastric T‐cell lymphoma, gastritis of the remnant stomach, esophageal adenocarcinoma, and esophageal squamous cell carcinoma. When nontypical lesions were excluded, the EBER1‐positive rate was 42.3% (11/26) in GCs. Of the 14 GC lesions ordered examined by endoscopists, three (21.4%) were EBVaGC. Eight of the 12 (66.7%) GCs ordered examined by pathologists were EBVaGC. CONCLUSIONS: The pathologic motif is expected to be useful and the endoscopic motif may be helpful for EBVaGC diagnosis.
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spelling pubmed-88281952022-03-17 Endoscopic and pathologic motifs for the clinical diagnosis of Epstein–Barr virus‐associated gastric cancer Yanai, Hideo Chihara, Daisuke Harano, Megumi Sakaguchi, Eiki Murakami, Tomoyuki Nishikawa, Jun DEN Open Original Articles OBJECTIVES: Based on the recent therapeutic trends for gastric cancer (GC), the clinical impact of the diagnosis of Epstein–Barr virus (EBV)‐associated GC (EBVaGC) appears to be important. We retrospectively analyzed endoscopic and pathologic motifs of GC lesions to narrow the number of candidates for EBV testing. METHODS: We performed EBV tests for 32 upper gastrointestinal lesions of 32 patients in the clinical setting. These tests were ordered by endoscopists or by pathologists without an endoscopist's order. EBV‐encoded small RNA1 (EBER1) in situ hybridization was used for the EBV tests. The endoscopic motif for the EBV test was the location in the upper part of the stomach or remnant stomach, mainly the depressed type with a submucosal tumor‐like protrusion of the lesion. The pathologic motif was carcinoma with lymphoid stroma (CLS) or CLS‐like histology of the lesion. We retrospectively analyzed the results of EBV tests for the endoscopic and pathologic motifs. RESULTS: The final pathological diagnoses of the 32 subjects were 26 GCs including CLS, gastric endocrine cell carcinoma, gastric hepatoid carcinoma, gastric T‐cell lymphoma, gastritis of the remnant stomach, esophageal adenocarcinoma, and esophageal squamous cell carcinoma. When nontypical lesions were excluded, the EBER1‐positive rate was 42.3% (11/26) in GCs. Of the 14 GC lesions ordered examined by endoscopists, three (21.4%) were EBVaGC. Eight of the 12 (66.7%) GCs ordered examined by pathologists were EBVaGC. CONCLUSIONS: The pathologic motif is expected to be useful and the endoscopic motif may be helpful for EBVaGC diagnosis. John Wiley and Sons Inc. 2021-04-21 /pmc/articles/PMC8828195/ /pubmed/35310151 http://dx.doi.org/10.1002/deo2.7 Text en © 2021 The Authors. DEN Open published by John Wiley & Sons Australia, Ltd on behalf of Japan Gastroenterological Endoscopy Society https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Yanai, Hideo
Chihara, Daisuke
Harano, Megumi
Sakaguchi, Eiki
Murakami, Tomoyuki
Nishikawa, Jun
Endoscopic and pathologic motifs for the clinical diagnosis of Epstein–Barr virus‐associated gastric cancer
title Endoscopic and pathologic motifs for the clinical diagnosis of Epstein–Barr virus‐associated gastric cancer
title_full Endoscopic and pathologic motifs for the clinical diagnosis of Epstein–Barr virus‐associated gastric cancer
title_fullStr Endoscopic and pathologic motifs for the clinical diagnosis of Epstein–Barr virus‐associated gastric cancer
title_full_unstemmed Endoscopic and pathologic motifs for the clinical diagnosis of Epstein–Barr virus‐associated gastric cancer
title_short Endoscopic and pathologic motifs for the clinical diagnosis of Epstein–Barr virus‐associated gastric cancer
title_sort endoscopic and pathologic motifs for the clinical diagnosis of epstein–barr virus‐associated gastric cancer
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828195/
https://www.ncbi.nlm.nih.gov/pubmed/35310151
http://dx.doi.org/10.1002/deo2.7
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