Cargando…

Application of Prognostic Models Based on Psoas Muscle Index, Stage, Pathological Grade, and Preoperative Carcinoembryonic Antigen Level in Stage II-III Colorectal Cancer Patients Undergoing Adjuvant Chemotherapy

OBJECTIVE: To investigate the effect of sarcopenia on the prognosis of stage II-III colorectal cancer patients undergoing adjuvant chemotherapy. METHODS: A total of 196 stage II-III colorectal cancer patients who received 8 cycles of postoperative chemotherapy were retrospectively analyzed. An abdom...

Descripción completa

Detalles Bibliográficos
Autores principales: Shan, Li, Li, Tian, Gu, Wenhao, Gao, Yuting, Zuo, Erdong, Qiu, Huizhu, Li, Rong, Cheng, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828329/
https://www.ncbi.nlm.nih.gov/pubmed/35154320
http://dx.doi.org/10.1155/2022/6851900
_version_ 1784647820105482240
author Shan, Li
Li, Tian
Gu, Wenhao
Gao, Yuting
Zuo, Erdong
Qiu, Huizhu
Li, Rong
Cheng, Xu
author_facet Shan, Li
Li, Tian
Gu, Wenhao
Gao, Yuting
Zuo, Erdong
Qiu, Huizhu
Li, Rong
Cheng, Xu
author_sort Shan, Li
collection PubMed
description OBJECTIVE: To investigate the effect of sarcopenia on the prognosis of stage II-III colorectal cancer patients undergoing adjuvant chemotherapy. METHODS: A total of 196 stage II-III colorectal cancer patients who received 8 cycles of postoperative chemotherapy were retrospectively analyzed. An abdominal CT acquired at 3-4 weeks after surgery was used to calculate the psoas muscle index. Subsequently, once gender-specific receiver operating characteristic curves were plotted and cut-off values of psoas muscle index were defined, the clinicopathological characteristics and the prognosis of patients with high and low values were compared. Lastly, prognostic models were established based on the independent prognostic factors of relapse-free survival and overall survival identified by COX analysis. RESULTS: Based on the psoas muscle index, the prevalence of sarcopenia was 37.5% among 196 patients. This prevalence has significant correlation with patients' age and gender. However, it was not related to the AJCC stage, T stage, lymph node metastasis, pathological grade, grade III-IV myelosuppression, or preoperative carcinoembryonic antigen level. In addition, both the relapse-free and the overall survival of patients with low and high psoas muscle indexes were significantly different. COX analysis indicated that the psoas muscle index was an independent prognostic factor. Both the overall survival prognostic model based on patients' psoas muscle index, stage, pathological grade, and preoperative carcinoembryonic antigen level and the relapse-free survival prognostic model based on patients' psoas muscle index, pathological grade, and preoperative carcinoembryonic antigen level could accurately predict the prognosis of patients. CONCLUSION: For stage II-III colorectal cancer patients, the presence of sarcopenia before adjuvant chemotherapy would adversely affect their recurrence-free and overall survival. Prognostic models based on psoas muscle index, stage, pathological grade, and preoperative carcinoembryonic antigen level could accurately predict the prognosis in these patients.
format Online
Article
Text
id pubmed-8828329
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-88283292022-02-10 Application of Prognostic Models Based on Psoas Muscle Index, Stage, Pathological Grade, and Preoperative Carcinoembryonic Antigen Level in Stage II-III Colorectal Cancer Patients Undergoing Adjuvant Chemotherapy Shan, Li Li, Tian Gu, Wenhao Gao, Yuting Zuo, Erdong Qiu, Huizhu Li, Rong Cheng, Xu J Oncol Research Article OBJECTIVE: To investigate the effect of sarcopenia on the prognosis of stage II-III colorectal cancer patients undergoing adjuvant chemotherapy. METHODS: A total of 196 stage II-III colorectal cancer patients who received 8 cycles of postoperative chemotherapy were retrospectively analyzed. An abdominal CT acquired at 3-4 weeks after surgery was used to calculate the psoas muscle index. Subsequently, once gender-specific receiver operating characteristic curves were plotted and cut-off values of psoas muscle index were defined, the clinicopathological characteristics and the prognosis of patients with high and low values were compared. Lastly, prognostic models were established based on the independent prognostic factors of relapse-free survival and overall survival identified by COX analysis. RESULTS: Based on the psoas muscle index, the prevalence of sarcopenia was 37.5% among 196 patients. This prevalence has significant correlation with patients' age and gender. However, it was not related to the AJCC stage, T stage, lymph node metastasis, pathological grade, grade III-IV myelosuppression, or preoperative carcinoembryonic antigen level. In addition, both the relapse-free and the overall survival of patients with low and high psoas muscle indexes were significantly different. COX analysis indicated that the psoas muscle index was an independent prognostic factor. Both the overall survival prognostic model based on patients' psoas muscle index, stage, pathological grade, and preoperative carcinoembryonic antigen level and the relapse-free survival prognostic model based on patients' psoas muscle index, pathological grade, and preoperative carcinoembryonic antigen level could accurately predict the prognosis of patients. CONCLUSION: For stage II-III colorectal cancer patients, the presence of sarcopenia before adjuvant chemotherapy would adversely affect their recurrence-free and overall survival. Prognostic models based on psoas muscle index, stage, pathological grade, and preoperative carcinoembryonic antigen level could accurately predict the prognosis in these patients. Hindawi 2022-02-02 /pmc/articles/PMC8828329/ /pubmed/35154320 http://dx.doi.org/10.1155/2022/6851900 Text en Copyright © 2022 Li Shan et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Shan, Li
Li, Tian
Gu, Wenhao
Gao, Yuting
Zuo, Erdong
Qiu, Huizhu
Li, Rong
Cheng, Xu
Application of Prognostic Models Based on Psoas Muscle Index, Stage, Pathological Grade, and Preoperative Carcinoembryonic Antigen Level in Stage II-III Colorectal Cancer Patients Undergoing Adjuvant Chemotherapy
title Application of Prognostic Models Based on Psoas Muscle Index, Stage, Pathological Grade, and Preoperative Carcinoembryonic Antigen Level in Stage II-III Colorectal Cancer Patients Undergoing Adjuvant Chemotherapy
title_full Application of Prognostic Models Based on Psoas Muscle Index, Stage, Pathological Grade, and Preoperative Carcinoembryonic Antigen Level in Stage II-III Colorectal Cancer Patients Undergoing Adjuvant Chemotherapy
title_fullStr Application of Prognostic Models Based on Psoas Muscle Index, Stage, Pathological Grade, and Preoperative Carcinoembryonic Antigen Level in Stage II-III Colorectal Cancer Patients Undergoing Adjuvant Chemotherapy
title_full_unstemmed Application of Prognostic Models Based on Psoas Muscle Index, Stage, Pathological Grade, and Preoperative Carcinoembryonic Antigen Level in Stage II-III Colorectal Cancer Patients Undergoing Adjuvant Chemotherapy
title_short Application of Prognostic Models Based on Psoas Muscle Index, Stage, Pathological Grade, and Preoperative Carcinoembryonic Antigen Level in Stage II-III Colorectal Cancer Patients Undergoing Adjuvant Chemotherapy
title_sort application of prognostic models based on psoas muscle index, stage, pathological grade, and preoperative carcinoembryonic antigen level in stage ii-iii colorectal cancer patients undergoing adjuvant chemotherapy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828329/
https://www.ncbi.nlm.nih.gov/pubmed/35154320
http://dx.doi.org/10.1155/2022/6851900
work_keys_str_mv AT shanli applicationofprognosticmodelsbasedonpsoasmuscleindexstagepathologicalgradeandpreoperativecarcinoembryonicantigenlevelinstageiiiiicolorectalcancerpatientsundergoingadjuvantchemotherapy
AT litian applicationofprognosticmodelsbasedonpsoasmuscleindexstagepathologicalgradeandpreoperativecarcinoembryonicantigenlevelinstageiiiiicolorectalcancerpatientsundergoingadjuvantchemotherapy
AT guwenhao applicationofprognosticmodelsbasedonpsoasmuscleindexstagepathologicalgradeandpreoperativecarcinoembryonicantigenlevelinstageiiiiicolorectalcancerpatientsundergoingadjuvantchemotherapy
AT gaoyuting applicationofprognosticmodelsbasedonpsoasmuscleindexstagepathologicalgradeandpreoperativecarcinoembryonicantigenlevelinstageiiiiicolorectalcancerpatientsundergoingadjuvantchemotherapy
AT zuoerdong applicationofprognosticmodelsbasedonpsoasmuscleindexstagepathologicalgradeandpreoperativecarcinoembryonicantigenlevelinstageiiiiicolorectalcancerpatientsundergoingadjuvantchemotherapy
AT qiuhuizhu applicationofprognosticmodelsbasedonpsoasmuscleindexstagepathologicalgradeandpreoperativecarcinoembryonicantigenlevelinstageiiiiicolorectalcancerpatientsundergoingadjuvantchemotherapy
AT lirong applicationofprognosticmodelsbasedonpsoasmuscleindexstagepathologicalgradeandpreoperativecarcinoembryonicantigenlevelinstageiiiiicolorectalcancerpatientsundergoingadjuvantchemotherapy
AT chengxu applicationofprognosticmodelsbasedonpsoasmuscleindexstagepathologicalgradeandpreoperativecarcinoembryonicantigenlevelinstageiiiiicolorectalcancerpatientsundergoingadjuvantchemotherapy