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Therapeutic Applications of Curcumin in Diabetes: A Review and Perspective

Diabetes is a metabolic disease with multifactorial causes which requires lifelong drug therapy as well as lifestyle changes. There is now growing scientific evidence to support the effectiveness of the use of herbal supplements in the prevention and control of diabetes. Curcumin is one of the most...

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Autores principales: Quispe, Cristina, Herrera-Bravo, Jesús, Javed, Zeeshan, Khan, Khushbukhat, Raza, Shahid, Gulsunoglu-Konuskan, Zehra, Daştan, Sevgi Durna, Sytar, Oksana, Martorell, Miquel, Sharifi-Rad, Javad, Calina, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828342/
https://www.ncbi.nlm.nih.gov/pubmed/35155670
http://dx.doi.org/10.1155/2022/1375892
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author Quispe, Cristina
Herrera-Bravo, Jesús
Javed, Zeeshan
Khan, Khushbukhat
Raza, Shahid
Gulsunoglu-Konuskan, Zehra
Daştan, Sevgi Durna
Sytar, Oksana
Martorell, Miquel
Sharifi-Rad, Javad
Calina, Daniela
author_facet Quispe, Cristina
Herrera-Bravo, Jesús
Javed, Zeeshan
Khan, Khushbukhat
Raza, Shahid
Gulsunoglu-Konuskan, Zehra
Daştan, Sevgi Durna
Sytar, Oksana
Martorell, Miquel
Sharifi-Rad, Javad
Calina, Daniela
author_sort Quispe, Cristina
collection PubMed
description Diabetes is a metabolic disease with multifactorial causes which requires lifelong drug therapy as well as lifestyle changes. There is now growing scientific evidence to support the effectiveness of the use of herbal supplements in the prevention and control of diabetes. Curcumin is one of the most studied bioactive components of traditional medicine, but its physicochemical characteristics are represented by low solubility, poor absorption, and low efficacy. Nanotechnology-based pharmaceutical formulations can help overcome the problems of reduced bioavailability of curcumin and increase its antidiabetic effects. The objectives of this review were to review the effects of nanocurcumin on DM and to search for databases such as PubMed/MEDLINE and ScienceDirect. The results showed that the antidiabetic activity of nanocurcumin is due to complex pharmacological mechanisms by reducing the characteristic hyperglycemia of DM. In light of these results, nanocurcumin may be considered as potential agent in the pharmacotherapeutic management of patients with diabetes.
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spelling pubmed-88283422022-02-10 Therapeutic Applications of Curcumin in Diabetes: A Review and Perspective Quispe, Cristina Herrera-Bravo, Jesús Javed, Zeeshan Khan, Khushbukhat Raza, Shahid Gulsunoglu-Konuskan, Zehra Daştan, Sevgi Durna Sytar, Oksana Martorell, Miquel Sharifi-Rad, Javad Calina, Daniela Biomed Res Int Review Article Diabetes is a metabolic disease with multifactorial causes which requires lifelong drug therapy as well as lifestyle changes. There is now growing scientific evidence to support the effectiveness of the use of herbal supplements in the prevention and control of diabetes. Curcumin is one of the most studied bioactive components of traditional medicine, but its physicochemical characteristics are represented by low solubility, poor absorption, and low efficacy. Nanotechnology-based pharmaceutical formulations can help overcome the problems of reduced bioavailability of curcumin and increase its antidiabetic effects. The objectives of this review were to review the effects of nanocurcumin on DM and to search for databases such as PubMed/MEDLINE and ScienceDirect. The results showed that the antidiabetic activity of nanocurcumin is due to complex pharmacological mechanisms by reducing the characteristic hyperglycemia of DM. In light of these results, nanocurcumin may be considered as potential agent in the pharmacotherapeutic management of patients with diabetes. Hindawi 2022-02-02 /pmc/articles/PMC8828342/ /pubmed/35155670 http://dx.doi.org/10.1155/2022/1375892 Text en Copyright © 2022 Cristina Quispe et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Quispe, Cristina
Herrera-Bravo, Jesús
Javed, Zeeshan
Khan, Khushbukhat
Raza, Shahid
Gulsunoglu-Konuskan, Zehra
Daştan, Sevgi Durna
Sytar, Oksana
Martorell, Miquel
Sharifi-Rad, Javad
Calina, Daniela
Therapeutic Applications of Curcumin in Diabetes: A Review and Perspective
title Therapeutic Applications of Curcumin in Diabetes: A Review and Perspective
title_full Therapeutic Applications of Curcumin in Diabetes: A Review and Perspective
title_fullStr Therapeutic Applications of Curcumin in Diabetes: A Review and Perspective
title_full_unstemmed Therapeutic Applications of Curcumin in Diabetes: A Review and Perspective
title_short Therapeutic Applications of Curcumin in Diabetes: A Review and Perspective
title_sort therapeutic applications of curcumin in diabetes: a review and perspective
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828342/
https://www.ncbi.nlm.nih.gov/pubmed/35155670
http://dx.doi.org/10.1155/2022/1375892
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