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The Pathogenesis and Long-Term Consequences of COVID-19 Cardiac Injury

The mechanisms of coronavirus disease-2019 (COVID-19)–related myocardial injury comprise both direct viral invasion and indirect (hypercoagulability and immune-mediated) cellular injuries. Some patients with COVID-19 cardiac involvement have poor clinical outcomes, with preliminary data suggesting l...

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Autores principales: Siripanthong, Bhurint, Asatryan, Babken, Hanff, Thomas C., Chatha, Salman R., Khanji, Mohammed Y., Ricci, Fabrizio, Muser, Daniele, Ferrari, Victor A., Nazarian, Saman, Santangeli, Pasquale, Deo, Rajat, Cooper, Leslie T., Mohiddin, Saidi A., Chahal, C. Anwar A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828362/
https://www.ncbi.nlm.nih.gov/pubmed/35165665
http://dx.doi.org/10.1016/j.jacbts.2021.10.011
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author Siripanthong, Bhurint
Asatryan, Babken
Hanff, Thomas C.
Chatha, Salman R.
Khanji, Mohammed Y.
Ricci, Fabrizio
Muser, Daniele
Ferrari, Victor A.
Nazarian, Saman
Santangeli, Pasquale
Deo, Rajat
Cooper, Leslie T.
Mohiddin, Saidi A.
Chahal, C. Anwar A.
author_facet Siripanthong, Bhurint
Asatryan, Babken
Hanff, Thomas C.
Chatha, Salman R.
Khanji, Mohammed Y.
Ricci, Fabrizio
Muser, Daniele
Ferrari, Victor A.
Nazarian, Saman
Santangeli, Pasquale
Deo, Rajat
Cooper, Leslie T.
Mohiddin, Saidi A.
Chahal, C. Anwar A.
author_sort Siripanthong, Bhurint
collection PubMed
description The mechanisms of coronavirus disease-2019 (COVID-19)–related myocardial injury comprise both direct viral invasion and indirect (hypercoagulability and immune-mediated) cellular injuries. Some patients with COVID-19 cardiac involvement have poor clinical outcomes, with preliminary data suggesting long-term structural and functional changes. These include persistent myocardial fibrosis, edema, and intraventricular thrombi with embolic events, while functionally, the left ventricle is enlarged, with a reduced ejection fraction and new-onset arrhythmias reported in a number of patients. Myocarditis post-COVID-19 vaccination is rare but more common among young male patients. Larger studies, including prospective data from biobanks, will be useful in expanding these early findings and determining their validity.
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spelling pubmed-88283622022-02-10 The Pathogenesis and Long-Term Consequences of COVID-19 Cardiac Injury Siripanthong, Bhurint Asatryan, Babken Hanff, Thomas C. Chatha, Salman R. Khanji, Mohammed Y. Ricci, Fabrizio Muser, Daniele Ferrari, Victor A. Nazarian, Saman Santangeli, Pasquale Deo, Rajat Cooper, Leslie T. Mohiddin, Saidi A. Chahal, C. Anwar A. JACC Basic Transl Sci State-of-the-Art Review The mechanisms of coronavirus disease-2019 (COVID-19)–related myocardial injury comprise both direct viral invasion and indirect (hypercoagulability and immune-mediated) cellular injuries. Some patients with COVID-19 cardiac involvement have poor clinical outcomes, with preliminary data suggesting long-term structural and functional changes. These include persistent myocardial fibrosis, edema, and intraventricular thrombi with embolic events, while functionally, the left ventricle is enlarged, with a reduced ejection fraction and new-onset arrhythmias reported in a number of patients. Myocarditis post-COVID-19 vaccination is rare but more common among young male patients. Larger studies, including prospective data from biobanks, will be useful in expanding these early findings and determining their validity. Elsevier 2022-02-09 /pmc/articles/PMC8828362/ /pubmed/35165665 http://dx.doi.org/10.1016/j.jacbts.2021.10.011 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle State-of-the-Art Review
Siripanthong, Bhurint
Asatryan, Babken
Hanff, Thomas C.
Chatha, Salman R.
Khanji, Mohammed Y.
Ricci, Fabrizio
Muser, Daniele
Ferrari, Victor A.
Nazarian, Saman
Santangeli, Pasquale
Deo, Rajat
Cooper, Leslie T.
Mohiddin, Saidi A.
Chahal, C. Anwar A.
The Pathogenesis and Long-Term Consequences of COVID-19 Cardiac Injury
title The Pathogenesis and Long-Term Consequences of COVID-19 Cardiac Injury
title_full The Pathogenesis and Long-Term Consequences of COVID-19 Cardiac Injury
title_fullStr The Pathogenesis and Long-Term Consequences of COVID-19 Cardiac Injury
title_full_unstemmed The Pathogenesis and Long-Term Consequences of COVID-19 Cardiac Injury
title_short The Pathogenesis and Long-Term Consequences of COVID-19 Cardiac Injury
title_sort pathogenesis and long-term consequences of covid-19 cardiac injury
topic State-of-the-Art Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828362/
https://www.ncbi.nlm.nih.gov/pubmed/35165665
http://dx.doi.org/10.1016/j.jacbts.2021.10.011
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