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Squidpy: a scalable framework for spatial omics analysis

Spatial omics data are advancing the study of tissue organization and cellular communication at an unprecedented scale. Flexible tools are required to store, integrate and visualize the large diversity of spatial omics data. Here, we present Squidpy, a Python framework that brings together tools fro...

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Autores principales: Palla, Giovanni, Spitzer, Hannah, Klein, Michal, Fischer, David, Schaar, Anna Christina, Kuemmerle, Louis Benedikt, Rybakov, Sergei, Ibarra, Ignacio L., Holmberg, Olle, Virshup, Isaac, Lotfollahi, Mohammad, Richter, Sabrina, Theis, Fabian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828470/
https://www.ncbi.nlm.nih.gov/pubmed/35102346
http://dx.doi.org/10.1038/s41592-021-01358-2
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author Palla, Giovanni
Spitzer, Hannah
Klein, Michal
Fischer, David
Schaar, Anna Christina
Kuemmerle, Louis Benedikt
Rybakov, Sergei
Ibarra, Ignacio L.
Holmberg, Olle
Virshup, Isaac
Lotfollahi, Mohammad
Richter, Sabrina
Theis, Fabian J.
author_facet Palla, Giovanni
Spitzer, Hannah
Klein, Michal
Fischer, David
Schaar, Anna Christina
Kuemmerle, Louis Benedikt
Rybakov, Sergei
Ibarra, Ignacio L.
Holmberg, Olle
Virshup, Isaac
Lotfollahi, Mohammad
Richter, Sabrina
Theis, Fabian J.
author_sort Palla, Giovanni
collection PubMed
description Spatial omics data are advancing the study of tissue organization and cellular communication at an unprecedented scale. Flexible tools are required to store, integrate and visualize the large diversity of spatial omics data. Here, we present Squidpy, a Python framework that brings together tools from omics and image analysis to enable scalable description of spatial molecular data, such as transcriptome or multivariate proteins. Squidpy provides efficient infrastructure and numerous analysis methods that allow to efficiently store, manipulate and interactively visualize spatial omics data. Squidpy is extensible and can be interfaced with a variety of already existing libraries for the scalable analysis of spatial omics data.
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spelling pubmed-88284702022-02-22 Squidpy: a scalable framework for spatial omics analysis Palla, Giovanni Spitzer, Hannah Klein, Michal Fischer, David Schaar, Anna Christina Kuemmerle, Louis Benedikt Rybakov, Sergei Ibarra, Ignacio L. Holmberg, Olle Virshup, Isaac Lotfollahi, Mohammad Richter, Sabrina Theis, Fabian J. Nat Methods Article Spatial omics data are advancing the study of tissue organization and cellular communication at an unprecedented scale. Flexible tools are required to store, integrate and visualize the large diversity of spatial omics data. Here, we present Squidpy, a Python framework that brings together tools from omics and image analysis to enable scalable description of spatial molecular data, such as transcriptome or multivariate proteins. Squidpy provides efficient infrastructure and numerous analysis methods that allow to efficiently store, manipulate and interactively visualize spatial omics data. Squidpy is extensible and can be interfaced with a variety of already existing libraries for the scalable analysis of spatial omics data. Nature Publishing Group US 2022-01-31 2022 /pmc/articles/PMC8828470/ /pubmed/35102346 http://dx.doi.org/10.1038/s41592-021-01358-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Palla, Giovanni
Spitzer, Hannah
Klein, Michal
Fischer, David
Schaar, Anna Christina
Kuemmerle, Louis Benedikt
Rybakov, Sergei
Ibarra, Ignacio L.
Holmberg, Olle
Virshup, Isaac
Lotfollahi, Mohammad
Richter, Sabrina
Theis, Fabian J.
Squidpy: a scalable framework for spatial omics analysis
title Squidpy: a scalable framework for spatial omics analysis
title_full Squidpy: a scalable framework for spatial omics analysis
title_fullStr Squidpy: a scalable framework for spatial omics analysis
title_full_unstemmed Squidpy: a scalable framework for spatial omics analysis
title_short Squidpy: a scalable framework for spatial omics analysis
title_sort squidpy: a scalable framework for spatial omics analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828470/
https://www.ncbi.nlm.nih.gov/pubmed/35102346
http://dx.doi.org/10.1038/s41592-021-01358-2
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