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The View Outside of the Box: Reporting Outcomes Following Radical Cystectomy Using Pentafecta From a Multicenter Retrospective Analysis
We aimed at characterization of the patients undergoing radical cystectomy (RC) using the prognostic model (a modified pentafecta). In the multicenter retrospective study, we enrolled 304 patients with bladder cancer (pTis-4N0-2M0) who underwent RC between 2015 and 2020 in experienced centers. The d...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828538/ https://www.ncbi.nlm.nih.gov/pubmed/35155267 http://dx.doi.org/10.3389/fonc.2022.841852 |
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author | Zapała, Łukasz Ślusarczyk, Aleksander Korczak, Bartłomiej Kurzyna, Paweł Leki, Mikołaj Lipiński, Piotr Miłow, Jerzy Niemczyk, Michał Pocheć, Kamil Późniak, Michał Przudzik, Maciej Suchojad, Tomasz Wolański, Rafał Zapała, Piotr Drewa, Tomasz Roslan, Marek Różański, Waldemar Wróbel, Andrzej Radziszewski, Piotr |
author_facet | Zapała, Łukasz Ślusarczyk, Aleksander Korczak, Bartłomiej Kurzyna, Paweł Leki, Mikołaj Lipiński, Piotr Miłow, Jerzy Niemczyk, Michał Pocheć, Kamil Późniak, Michał Przudzik, Maciej Suchojad, Tomasz Wolański, Rafał Zapała, Piotr Drewa, Tomasz Roslan, Marek Różański, Waldemar Wróbel, Andrzej Radziszewski, Piotr |
author_sort | Zapała, Łukasz |
collection | PubMed |
description | We aimed at characterization of the patients undergoing radical cystectomy (RC) using the prognostic model (a modified pentafecta). In the multicenter retrospective study, we enrolled 304 patients with bladder cancer (pTis-4N0-2M0) who underwent RC between 2015 and 2020 in experienced centers. The definition of the pentafecta was as follows: no Clavien–Dindo grade III–V complications at 90 days and no long-term complications related to urinary diversion <12 months, negative surgical margins, ≥10 lymph nodes (LNs) resected, and no recurrence ≤12 months. RC-pentafecta achievement rate was 22% (n = 67), varying from 47% to 88% attainment rate for different pentafecta components, and was the lowest for sufficient LN yield. Both 12-month recurrence-free survival (RFS) and cancer-specific mortality were compromised in pentafecta failers compared with achievers (57.8% vs. 100% and 33.8% vs. 1.5%, respectively). The following were identified as crucial predictors of RC pentafecta achievement: modality of the surgery, type of urinary diversion, histological type of bladder cancer, advanced staging, and elevated preoperative serum creatinine. In conclusion, we found that the pentafecta achievement rate was low even in high-volume centers in patients undergoing cystectomy. The complexity of the procedure directly influenced the attainment rate, which in turn led to an increase in cancer-specific mortality rate among the pentafecta failers. |
format | Online Article Text |
id | pubmed-8828538 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88285382022-02-11 The View Outside of the Box: Reporting Outcomes Following Radical Cystectomy Using Pentafecta From a Multicenter Retrospective Analysis Zapała, Łukasz Ślusarczyk, Aleksander Korczak, Bartłomiej Kurzyna, Paweł Leki, Mikołaj Lipiński, Piotr Miłow, Jerzy Niemczyk, Michał Pocheć, Kamil Późniak, Michał Przudzik, Maciej Suchojad, Tomasz Wolański, Rafał Zapała, Piotr Drewa, Tomasz Roslan, Marek Różański, Waldemar Wróbel, Andrzej Radziszewski, Piotr Front Oncol Oncology We aimed at characterization of the patients undergoing radical cystectomy (RC) using the prognostic model (a modified pentafecta). In the multicenter retrospective study, we enrolled 304 patients with bladder cancer (pTis-4N0-2M0) who underwent RC between 2015 and 2020 in experienced centers. The definition of the pentafecta was as follows: no Clavien–Dindo grade III–V complications at 90 days and no long-term complications related to urinary diversion <12 months, negative surgical margins, ≥10 lymph nodes (LNs) resected, and no recurrence ≤12 months. RC-pentafecta achievement rate was 22% (n = 67), varying from 47% to 88% attainment rate for different pentafecta components, and was the lowest for sufficient LN yield. Both 12-month recurrence-free survival (RFS) and cancer-specific mortality were compromised in pentafecta failers compared with achievers (57.8% vs. 100% and 33.8% vs. 1.5%, respectively). The following were identified as crucial predictors of RC pentafecta achievement: modality of the surgery, type of urinary diversion, histological type of bladder cancer, advanced staging, and elevated preoperative serum creatinine. In conclusion, we found that the pentafecta achievement rate was low even in high-volume centers in patients undergoing cystectomy. The complexity of the procedure directly influenced the attainment rate, which in turn led to an increase in cancer-specific mortality rate among the pentafecta failers. Frontiers Media S.A. 2022-01-26 /pmc/articles/PMC8828538/ /pubmed/35155267 http://dx.doi.org/10.3389/fonc.2022.841852 Text en Copyright © 2022 Zapała, Ślusarczyk, Korczak, Kurzyna, Leki, Lipiński, Miłow, Niemczyk, Pocheć, Późniak, Przudzik, Suchojad, Wolański, Zapała, Drewa, Roslan, Różański, Wróbel and Radziszewski https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Zapała, Łukasz Ślusarczyk, Aleksander Korczak, Bartłomiej Kurzyna, Paweł Leki, Mikołaj Lipiński, Piotr Miłow, Jerzy Niemczyk, Michał Pocheć, Kamil Późniak, Michał Przudzik, Maciej Suchojad, Tomasz Wolański, Rafał Zapała, Piotr Drewa, Tomasz Roslan, Marek Różański, Waldemar Wróbel, Andrzej Radziszewski, Piotr The View Outside of the Box: Reporting Outcomes Following Radical Cystectomy Using Pentafecta From a Multicenter Retrospective Analysis |
title | The View Outside of the Box: Reporting Outcomes Following Radical Cystectomy Using Pentafecta From a Multicenter Retrospective Analysis |
title_full | The View Outside of the Box: Reporting Outcomes Following Radical Cystectomy Using Pentafecta From a Multicenter Retrospective Analysis |
title_fullStr | The View Outside of the Box: Reporting Outcomes Following Radical Cystectomy Using Pentafecta From a Multicenter Retrospective Analysis |
title_full_unstemmed | The View Outside of the Box: Reporting Outcomes Following Radical Cystectomy Using Pentafecta From a Multicenter Retrospective Analysis |
title_short | The View Outside of the Box: Reporting Outcomes Following Radical Cystectomy Using Pentafecta From a Multicenter Retrospective Analysis |
title_sort | view outside of the box: reporting outcomes following radical cystectomy using pentafecta from a multicenter retrospective analysis |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828538/ https://www.ncbi.nlm.nih.gov/pubmed/35155267 http://dx.doi.org/10.3389/fonc.2022.841852 |
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