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Multi-layered regulation of neuroectoderm differentiation by retinoic acid in a primitive streak-like context
The formation of the primitive streak (PS) and the subsequent induction of neuroectoderm are hallmarks of gastrulation. Combining an in vitro reconstitution of this process based on mouse embryonic stem cells (mESCs) with a collection of knockouts in reporter mESC lines, we identified retinoic acid...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828549/ https://www.ncbi.nlm.nih.gov/pubmed/35063128 http://dx.doi.org/10.1016/j.stemcr.2021.12.014 |