Human iPSC model reveals a central role for NOX4 and oxidative stress in Duchenne cardiomyopathy

Duchenne muscular dystrophy (DMD) is a progressive muscle disorder caused by mutations in the Dystrophin gene. Cardiomyopathy is a major cause of early death. We used DMD-patient-specific human induced pluripotent stem cells (hiPSCs) to model cardiomyopathic features and unravel novel pathologic ins...

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Detalles Bibliográficos
Autores principales: Duelen, Robin, Costamagna, Domiziana, Gilbert, Guillaume, Waele, Liesbeth De, Goemans, Nathalie, Desloovere, Kaat, Verfaillie, Catherine M., Sipido, Karin R., Buyse, Gunnar M., Sampaolesi, Maurilio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828550/
https://www.ncbi.nlm.nih.gov/pubmed/35090586
http://dx.doi.org/10.1016/j.stemcr.2021.12.019

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