Cargando…
Porencephaly with an optic organ abnormality in a beagle dog
A female TOYO beagle dog showed porencephaly and visual organ abnormalities. At necropsy, there was a cavity filled with cerebrospinal fluid in the right cerebral hemisphere and an adhesion area between the cerebral cortex and the skull, which was partially thickened. Additionally, the right optic n...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Japanese Society of Toxicologic Pathology
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828607/ https://www.ncbi.nlm.nih.gov/pubmed/35221503 http://dx.doi.org/10.1293/tox.2021-0039 |
_version_ | 1784647886078738432 |
---|---|
author | Hashiguchi, Osamu Yamaguchi, Yuko Ikezaki, Shinichiro Saito, Tsubasa Igura, Saori Hirai, Ryo Horiuchi, Naomi Tamura, Kazutoshi |
author_facet | Hashiguchi, Osamu Yamaguchi, Yuko Ikezaki, Shinichiro Saito, Tsubasa Igura, Saori Hirai, Ryo Horiuchi, Naomi Tamura, Kazutoshi |
author_sort | Hashiguchi, Osamu |
collection | PubMed |
description | A female TOYO beagle dog showed porencephaly and visual organ abnormalities. At necropsy, there was a cavity filled with cerebrospinal fluid in the right cerebral hemisphere and an adhesion area between the cerebral cortex and the skull, which was partially thickened. Additionally, the right optic nerve showed a slight decrease in diameter. Histopathological examination revealed increased glial fibers and collagen fibers, hemosiderin deposition, and an increased number of microglia in the adhesion area, along with a marked reduction of the cerebral parenchyma. In the right eyeball, the retina and optic nerve showed focal atrophy in the nerve fiber layer and inner granular layer to full retinal atrophy and hypoplasia of the myelinated nerve fibers, respectively. Electron microscopic examination revealed hypoplasia of the myelin sheath of nerve fibers in the right optic nerve. This is an extremely rare case of porencephaly and congenital optic nerve hypoplasia, along with independent retinal thinning. |
format | Online Article Text |
id | pubmed-8828607 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Japanese Society of Toxicologic Pathology |
record_format | MEDLINE/PubMed |
spelling | pubmed-88286072022-02-25 Porencephaly with an optic organ abnormality in a beagle dog Hashiguchi, Osamu Yamaguchi, Yuko Ikezaki, Shinichiro Saito, Tsubasa Igura, Saori Hirai, Ryo Horiuchi, Naomi Tamura, Kazutoshi J Toxicol Pathol Case Report A female TOYO beagle dog showed porencephaly and visual organ abnormalities. At necropsy, there was a cavity filled with cerebrospinal fluid in the right cerebral hemisphere and an adhesion area between the cerebral cortex and the skull, which was partially thickened. Additionally, the right optic nerve showed a slight decrease in diameter. Histopathological examination revealed increased glial fibers and collagen fibers, hemosiderin deposition, and an increased number of microglia in the adhesion area, along with a marked reduction of the cerebral parenchyma. In the right eyeball, the retina and optic nerve showed focal atrophy in the nerve fiber layer and inner granular layer to full retinal atrophy and hypoplasia of the myelinated nerve fibers, respectively. Electron microscopic examination revealed hypoplasia of the myelin sheath of nerve fibers in the right optic nerve. This is an extremely rare case of porencephaly and congenital optic nerve hypoplasia, along with independent retinal thinning. Japanese Society of Toxicologic Pathology 2021-10-25 2022-01 /pmc/articles/PMC8828607/ /pubmed/35221503 http://dx.doi.org/10.1293/tox.2021-0039 Text en ©2022 The Japanese Society of Toxicologic Pathology https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Hashiguchi, Osamu Yamaguchi, Yuko Ikezaki, Shinichiro Saito, Tsubasa Igura, Saori Hirai, Ryo Horiuchi, Naomi Tamura, Kazutoshi Porencephaly with an optic organ abnormality in a beagle dog |
title | Porencephaly with an optic organ abnormality in a beagle dog |
title_full | Porencephaly with an optic organ abnormality in a beagle dog |
title_fullStr | Porencephaly with an optic organ abnormality in a beagle dog |
title_full_unstemmed | Porencephaly with an optic organ abnormality in a beagle dog |
title_short | Porencephaly with an optic organ abnormality in a beagle dog |
title_sort | porencephaly with an optic organ abnormality in a beagle dog |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828607/ https://www.ncbi.nlm.nih.gov/pubmed/35221503 http://dx.doi.org/10.1293/tox.2021-0039 |
work_keys_str_mv | AT hashiguchiosamu porencephalywithanopticorganabnormalityinabeagledog AT yamaguchiyuko porencephalywithanopticorganabnormalityinabeagledog AT ikezakishinichiro porencephalywithanopticorganabnormalityinabeagledog AT saitotsubasa porencephalywithanopticorganabnormalityinabeagledog AT igurasaori porencephalywithanopticorganabnormalityinabeagledog AT hirairyo porencephalywithanopticorganabnormalityinabeagledog AT horiuchinaomi porencephalywithanopticorganabnormalityinabeagledog AT tamurakazutoshi porencephalywithanopticorganabnormalityinabeagledog |