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Chronic otitis externa with heat shock protein 70-positive intranuclear inclusion bodies in the ceruminous gland epithelium of a Chihuahua dog
A Chihuahua dog showed persistent itching in the right ear canal. Anti-inflammatory medicines and prednisolone were ineffective and total ear canal ablation was performed. Histological diagnosis was chronic otitis externa. Eosinophilic intranuclear inclusion bodies (Cowdry type A and full-type) were...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Japanese Society of Toxicologic Pathology
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828612/ https://www.ncbi.nlm.nih.gov/pubmed/35221498 http://dx.doi.org/10.1293/tox.2021-0033 |
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author | Kiuchi, Takeru Watanabe, Kenichi Nakagun, Shotaro Miyahara, Kazurou Horiuchi, Noriyuki Kobayashi, Yoshiyasu |
author_facet | Kiuchi, Takeru Watanabe, Kenichi Nakagun, Shotaro Miyahara, Kazurou Horiuchi, Noriyuki Kobayashi, Yoshiyasu |
author_sort | Kiuchi, Takeru |
collection | PubMed |
description | A Chihuahua dog showed persistent itching in the right ear canal. Anti-inflammatory medicines and prednisolone were ineffective and total ear canal ablation was performed. Histological diagnosis was chronic otitis externa. Eosinophilic intranuclear inclusion bodies (Cowdry type A and full-type) were occasionally observed in the ceruminous gland epithelium. The inclusion bodies were negative for nucleic acid and ultrastructurally composed of fibrous structures (approximately 10 nm in width). Viral infection was initially suspected, but polymelase chain reaction tests did not detect the expected viral genes. Immunohistochemistry revealed that the inclusion bodies were positive for heat shock protein 70 (HSP70), suggesting that these bodies could be protein aggregates including HSP70. The etiology of this lesion has not been elucidated, but chronic inflammation may influence the cytoplasm-to-nuclear transportation of HSP70. To the best of our knowledge, this is the first report of canine chronic otitis externa with HSP70-positive intranuclear inclusion bodies. |
format | Online Article Text |
id | pubmed-8828612 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Japanese Society of Toxicologic Pathology |
record_format | MEDLINE/PubMed |
spelling | pubmed-88286122022-02-25 Chronic otitis externa with heat shock protein 70-positive intranuclear inclusion bodies in the ceruminous gland epithelium of a Chihuahua dog Kiuchi, Takeru Watanabe, Kenichi Nakagun, Shotaro Miyahara, Kazurou Horiuchi, Noriyuki Kobayashi, Yoshiyasu J Toxicol Pathol Case Report A Chihuahua dog showed persistent itching in the right ear canal. Anti-inflammatory medicines and prednisolone were ineffective and total ear canal ablation was performed. Histological diagnosis was chronic otitis externa. Eosinophilic intranuclear inclusion bodies (Cowdry type A and full-type) were occasionally observed in the ceruminous gland epithelium. The inclusion bodies were negative for nucleic acid and ultrastructurally composed of fibrous structures (approximately 10 nm in width). Viral infection was initially suspected, but polymelase chain reaction tests did not detect the expected viral genes. Immunohistochemistry revealed that the inclusion bodies were positive for heat shock protein 70 (HSP70), suggesting that these bodies could be protein aggregates including HSP70. The etiology of this lesion has not been elucidated, but chronic inflammation may influence the cytoplasm-to-nuclear transportation of HSP70. To the best of our knowledge, this is the first report of canine chronic otitis externa with HSP70-positive intranuclear inclusion bodies. Japanese Society of Toxicologic Pathology 2021-08-28 2022-01 /pmc/articles/PMC8828612/ /pubmed/35221498 http://dx.doi.org/10.1293/tox.2021-0033 Text en ©2022 The Japanese Society of Toxicologic Pathology https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Kiuchi, Takeru Watanabe, Kenichi Nakagun, Shotaro Miyahara, Kazurou Horiuchi, Noriyuki Kobayashi, Yoshiyasu Chronic otitis externa with heat shock protein 70-positive intranuclear inclusion bodies in the ceruminous gland epithelium of a Chihuahua dog |
title | Chronic otitis externa with heat shock protein 70-positive intranuclear
inclusion bodies in the ceruminous gland epithelium of a Chihuahua dog |
title_full | Chronic otitis externa with heat shock protein 70-positive intranuclear
inclusion bodies in the ceruminous gland epithelium of a Chihuahua dog |
title_fullStr | Chronic otitis externa with heat shock protein 70-positive intranuclear
inclusion bodies in the ceruminous gland epithelium of a Chihuahua dog |
title_full_unstemmed | Chronic otitis externa with heat shock protein 70-positive intranuclear
inclusion bodies in the ceruminous gland epithelium of a Chihuahua dog |
title_short | Chronic otitis externa with heat shock protein 70-positive intranuclear
inclusion bodies in the ceruminous gland epithelium of a Chihuahua dog |
title_sort | chronic otitis externa with heat shock protein 70-positive intranuclear
inclusion bodies in the ceruminous gland epithelium of a chihuahua dog |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828612/ https://www.ncbi.nlm.nih.gov/pubmed/35221498 http://dx.doi.org/10.1293/tox.2021-0033 |
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