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Use of the Advanced Lung Cancer Inflammation Index as a Prognostic Indicator for Patients With Cholangiocarcinoma
BACKGROUND: This study aimed to assess the clinical utility of the advanced lung cancer inflammation index (ALI) as a prognostic indicator for patients with cholangiocarcinoma (CCA) and construct a prognostic nomogram based on ALI. METHODS: A total of 97 CCA patients who received radical resection w...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828638/ https://www.ncbi.nlm.nih.gov/pubmed/35155556 http://dx.doi.org/10.3389/fsurg.2022.801767 |
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author | Wu, Huasheng Ding, Fadian Lin, Meitai Shi, Zheng Mei, Zhengzhou Chen, Shaoqin Jiang, Chao Qiu, Huabin Zheng, Zhenhua Chen, Youting Zhao, Peng |
author_facet | Wu, Huasheng Ding, Fadian Lin, Meitai Shi, Zheng Mei, Zhengzhou Chen, Shaoqin Jiang, Chao Qiu, Huabin Zheng, Zhenhua Chen, Youting Zhao, Peng |
author_sort | Wu, Huasheng |
collection | PubMed |
description | BACKGROUND: This study aimed to assess the clinical utility of the advanced lung cancer inflammation index (ALI) as a prognostic indicator for patients with cholangiocarcinoma (CCA) and construct a prognostic nomogram based on ALI. METHODS: A total of 97 CCA patients who received radical resection were included. The optimal cut-off point for ALI was identified by X-tile analysis. COX regression analysis were used to identify risk factors of overall survival (OS) and disease-free survival (DFS). A predictive nomogram for DFS was constructed. RESULTS: The optimal cut-off value for preoperative ALI was 31.8. 35 (36.1%) patients were categorized into the low-ALI group and 62 (63.9%) patients into the high-ALI group. Low ALI was independently associated with hypoproteinemia and lower body mass index (BMI) (all P < 0.05). COX regression analysis revealed that preoperative ALI level (HR = 0.974, P = 0.037) and pathological TNM stage (HR = 7.331, P < 0.001) were independently correlated with OS for patients with CCA, and preoperative ALI level (HR = 0.978, P = 0.042) and pathological T stage (HR = 1.473, P = 0.035) remained to be independent prognostic factors for DFS in CCA patients. Using time-dependent ROC analysis, we found that ALI was better at predicting prognosis than other parameters, such as neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and prognostic nutritional index (PNI) in terms of OS and DFS. A nomogram predicting DFS was built (C-index: 0.73 95%CI: 0.67–0.79). CONCLUSIONS: ALI may be useful for prognosis assessment for patients with CCA. |
format | Online Article Text |
id | pubmed-8828638 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88286382022-02-11 Use of the Advanced Lung Cancer Inflammation Index as a Prognostic Indicator for Patients With Cholangiocarcinoma Wu, Huasheng Ding, Fadian Lin, Meitai Shi, Zheng Mei, Zhengzhou Chen, Shaoqin Jiang, Chao Qiu, Huabin Zheng, Zhenhua Chen, Youting Zhao, Peng Front Surg Surgery BACKGROUND: This study aimed to assess the clinical utility of the advanced lung cancer inflammation index (ALI) as a prognostic indicator for patients with cholangiocarcinoma (CCA) and construct a prognostic nomogram based on ALI. METHODS: A total of 97 CCA patients who received radical resection were included. The optimal cut-off point for ALI was identified by X-tile analysis. COX regression analysis were used to identify risk factors of overall survival (OS) and disease-free survival (DFS). A predictive nomogram for DFS was constructed. RESULTS: The optimal cut-off value for preoperative ALI was 31.8. 35 (36.1%) patients were categorized into the low-ALI group and 62 (63.9%) patients into the high-ALI group. Low ALI was independently associated with hypoproteinemia and lower body mass index (BMI) (all P < 0.05). COX regression analysis revealed that preoperative ALI level (HR = 0.974, P = 0.037) and pathological TNM stage (HR = 7.331, P < 0.001) were independently correlated with OS for patients with CCA, and preoperative ALI level (HR = 0.978, P = 0.042) and pathological T stage (HR = 1.473, P = 0.035) remained to be independent prognostic factors for DFS in CCA patients. Using time-dependent ROC analysis, we found that ALI was better at predicting prognosis than other parameters, such as neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and prognostic nutritional index (PNI) in terms of OS and DFS. A nomogram predicting DFS was built (C-index: 0.73 95%CI: 0.67–0.79). CONCLUSIONS: ALI may be useful for prognosis assessment for patients with CCA. Frontiers Media S.A. 2022-01-27 /pmc/articles/PMC8828638/ /pubmed/35155556 http://dx.doi.org/10.3389/fsurg.2022.801767 Text en Copyright © 2022 Wu, Ding, Lin, Shi, Mei, Chen, Jiang, Qiu, Zheng, Chen and Zhao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Surgery Wu, Huasheng Ding, Fadian Lin, Meitai Shi, Zheng Mei, Zhengzhou Chen, Shaoqin Jiang, Chao Qiu, Huabin Zheng, Zhenhua Chen, Youting Zhao, Peng Use of the Advanced Lung Cancer Inflammation Index as a Prognostic Indicator for Patients With Cholangiocarcinoma |
title | Use of the Advanced Lung Cancer Inflammation Index as a Prognostic Indicator for Patients With Cholangiocarcinoma |
title_full | Use of the Advanced Lung Cancer Inflammation Index as a Prognostic Indicator for Patients With Cholangiocarcinoma |
title_fullStr | Use of the Advanced Lung Cancer Inflammation Index as a Prognostic Indicator for Patients With Cholangiocarcinoma |
title_full_unstemmed | Use of the Advanced Lung Cancer Inflammation Index as a Prognostic Indicator for Patients With Cholangiocarcinoma |
title_short | Use of the Advanced Lung Cancer Inflammation Index as a Prognostic Indicator for Patients With Cholangiocarcinoma |
title_sort | use of the advanced lung cancer inflammation index as a prognostic indicator for patients with cholangiocarcinoma |
topic | Surgery |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828638/ https://www.ncbi.nlm.nih.gov/pubmed/35155556 http://dx.doi.org/10.3389/fsurg.2022.801767 |
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