Combining p53 mRNA nanotherapy with immune checkpoint blockade reprograms the immune microenvironment for effective cancer therapy

Immunotherapy with immune checkpoint blockade (ICB) has shown limited benefits in hepatocellular carcinoma (HCC) and other cancers, mediated in part by the immunosuppressive tumor microenvironment (TME). As p53 loss of function may play a role in immunosuppression, we herein examine the effects of r...

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Detalles Bibliográficos
Autores principales: Xiao, Yuling, Chen, Jiang, Zhou, Hui, Zeng, Xiaodong, Ruan, Zhiping, Pu, Zhangya, Jiang, Xingya, Matsui, Aya, Zhu, Lingling, Amoozgar, Zohreh, Chen, Dean Shuailin, Han, Xiangfei, Duda, Dan G., Shi, Jinjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828745/
https://www.ncbi.nlm.nih.gov/pubmed/35140208
http://dx.doi.org/10.1038/s41467-022-28279-8

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