A diencephalic circuit in rats for opioid analgesia but not positive reinforcement

Mu opioid receptor (MOR) agonists are potent analgesics, but also cause sedation, respiratory depression, and addiction risk. The epithalamic lateral habenula (LHb) signals aversive states including pain, and here we found that it is a potent site for MOR-agonist analgesia-like responses in rats. Im...

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Detalles Bibliográficos
Autores principales: Waung, Maggie W., Maanum, Kayla A., Cirino, Thomas J., Driscoll, Joseph R., O’Brien, Chris, Bryant, Svetlana, Mansourian, Kasra A., Morales, Marisela, Barker, David J., Margolis, Elyssa B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828762/
https://www.ncbi.nlm.nih.gov/pubmed/35140231
http://dx.doi.org/10.1038/s41467-022-28332-6

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