Prime editing efficiency and fidelity are enhanced in the absence of mismatch repair

Prime editing (PE) is a powerful genome engineering approach that enables the introduction of base substitutions, insertions and deletions into any given genomic locus. However, the efficiency of PE varies widely and depends not only on the genomic region targeted, but also on the genetic background...

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Detalles Bibliográficos
Autores principales: Ferreira da Silva, J., Oliveira, G. P., Arasa-Verge, E. A., Kagiou, C., Moretton, A., Timelthaler, G., Jiricny, J., Loizou, J. I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828784/
https://www.ncbi.nlm.nih.gov/pubmed/35140211
http://dx.doi.org/10.1038/s41467-022-28442-1

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