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Cryo-EM structure of transcription termination factor Rho from Mycobacterium tuberculosis reveals bicyclomycin resistance mechanism

The bacterial Rho factor is a ring-shaped motor triggering genome-wide transcription termination and R-loop dissociation. Rho is essential in many species, including in Mycobacterium tuberculosis where rho gene inactivation leads to rapid death. Yet, the M. tuberculosis Rho [(Mtb)Rho] factor display...

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Detalles Bibliográficos
Autores principales:	Saridakis, Emmanuel, Vishwakarma, Rishi, Lai-Kee-Him, Josephine, Martin, Kevin, Simon, Isabelle, Cohen-Gonsaud, Martin, Coste, Franck, Bron, Patrick, Margeat, Emmanuel, Boudvillain, Marc
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828861/ https://www.ncbi.nlm.nih.gov/pubmed/35140348 http://dx.doi.org/10.1038/s42003-022-03069-6

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