Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance

Evidence suggests that caffeine (CF) reduces cardiovascular disease (CVD) risk. However, the mechanism by which this occurs has not yet been uncovered. Here, we investigated the effect of CF on the expression of two bona fide regulators of circulating low-density lipoprotein cholesterol (LDLc) level...

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Detalles Bibliográficos
Autores principales: Lebeau, Paul F., Byun, Jae Hyun, Platko, Khrystyna, Saliba, Paul, Sguazzin, Matthew, MacDonald, Melissa E., Paré, Guillaume, Steinberg, Gregory R., Janssen, Luke J., Igdoura, Suleiman A., Tarnopolsky, Mark A., Wayne Chen, S. R., Seidah, Nabil G., Magolan, Jakob, Austin, Richard C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828868/
https://www.ncbi.nlm.nih.gov/pubmed/35140212
http://dx.doi.org/10.1038/s41467-022-28240-9

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