Cargando…

Critical discussion on drug efflux in Mycobacterium tuberculosis

Mycobacterium tuberculosis (Mtb) can withstand months of antibiotic treatment. An important goal of tuberculosis research is to shorten the treatment to reduce the burden on patients, increase adherence to the drug regimen and thereby slow down the spread of drug resistance. Inhibition of drug efflu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Remm, Sille, Earp, Jennifer C, Dick, Thomas, Dartois, Véronique, Seeger, Markus A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829022/ https://www.ncbi.nlm.nih.gov/pubmed/34637511 http://dx.doi.org/10.1093/femsre/fuab050

Ejemplares similares

The Role of Transport Mechanisms in Mycobacterium Tuberculosis Drug Resistance and Tolerance
por: Sarathy, Jansy Passiflora, et al.
Publicado: (2012)

Mycobacterium tuberculosis DprE1 Inhibitor OPC-167832 Is Active against Mycobacterium abscessus In Vitro
por: Sarathy, Jickky Palmae, et al.
Publicado: (2022)

Verapamil Targets Membrane Energetics in Mycobacterium tuberculosis
por: Chen, Chao, et al.
Publicado: (2018)

A Ginger Root or Plum Model for the Tuberculosis “Granuloma”?
por: Dartois, Véronique, et al.
Publicado: (2021)

Extreme Drug Tolerance of Mycobacterium tuberculosis in Caseum
por: Sarathy, Jansy P., et al.
Publicado: (2018)

Characterization of In Vitro Resistance to Linezolid in Mycobacterium abscessus
por: Negatu, Dereje A., et al.
Publicado: (2023)

Interplay between Mutations and Efflux in Drug Resistant Clinical Isolates of Mycobacterium tuberculosis
por: Machado, Diana, et al.
Publicado: (2017)

Anti-tuberculosis treatment strategies and drug development: challenges and priorities
por: Dartois, Véronique A., et al.
Publicado: (2022)

Drug development challenges in nontuberculous mycobacterial lung disease: TB to the rescue
por: Dartois, Véronique, et al.
Publicado: (2022)

Gut Microbiota Metabolite Indole Propionic Acid Targets Tryptophan Biosynthesis in Mycobacterium tuberculosis
por: Negatu, Dereje Abate, et al.
Publicado: (2019)

A Mycobacterium tuberculosis NBTI DNA Gyrase Inhibitor Is Active against Mycobacterium abscessus
por: Ganapathy, Uday S., et al.
Publicado: (2021)

Phenoxyalkylimidazoles with an oxadiazole moiety are subject to efflux in Mycobacterium tuberculosis
por: Thayer, Mai B., et al.
Publicado: (2021)

Rifabutin Is Active against Mycobacterium abscessus in Mice
por: Dick, Thomas, et al.
Publicado: (2020)

Teicoplanin – Tigecycline Combination Shows Synergy Against Mycobacterium abscessus
por: Aziz, Dinah B., et al.
Publicado: (2018)

Effect of efflux pump inhibitors on drug susceptibility of ofloxacin resistant Mycobacterium tuberculosis isolates
por: Singh, Mradula, et al.
Publicado: (2011)

In Silico Approach for Phytocompound-Based Drug Designing to Fight Efflux Pump-Mediated Multidrug-Resistant Mycobacterium tuberculosis
por: Biswas, Santasree Sarma, et al.
Publicado: (2021)

Strongly Bactericidal All-Oral β-Lactam Combinations for the Treatment of Mycobacterium abscessus Lung Disease
por: Negatu, Dereje A., et al.
Publicado: (2022)

Contribution of Efflux to the Emergence of Isoniazid and Multidrug Resistance in Mycobacterium tuberculosis
por: Machado, Diana, et al.
Publicado: (2012)

Effect of efflux pump inhibitors on the susceptibility of Mycobacterium tuberculosis to isoniazid
por: Jaiswal, Indu, et al.
Publicado: (2017)

Characterization of the Mycobacterial MSMEG-3762/63 Efflux Pump in Mycobacterium smegmatis Drug Efflux
por: De Siena, Barbara, et al.
Publicado: (2020)

Scrutinizing the drug resistance mechanism of multi- and extensively-drug resistant Mycobacterium tuberculosis: mutations versus efflux pumps
por: Ghajavand, Hasan, et al.
Publicado: (2019)

In Vitro Profiling of the Synthetic RNA Polymerase Inhibitor MMV688845 against Mycobacterium abscessus
por: Mann, Lea, et al.
Publicado: (2022)

Immune activation of the host cell induces drug tolerance in Mycobacterium tuberculosis both in vitro and in vivo
por: Liu, Yancheng, et al.
Publicado: (2016)

Potency boost of a Mycobacterium tuberculosis dihydrofolate reductase inhibitor by multienzyme F(420)H(2)-dependent reduction
por: Aragaw, Wassihun Wedajo, et al.
Publicado: (2021)

Matrix metalloproteinase inhibitors enhance the efficacy of frontline drugs against Mycobacterium tuberculosis
por: Xu, Yitian, et al.
Publicado: (2018)

Increased drug permeability of a stiffened mycobacterial outer membrane in cells lacking MFS transporter Rv1410 and lipoprotein LprG
por: Hohl, Michael, et al.
Publicado: (2019)

Plasticity of the Mycobacterium tuberculosis respiratory chain and its impact on tuberculosis drug development
por: Beites, Tiago, et al.
Publicado: (2019)

In Vivo-Selected Pyrazinoic Acid-Resistant Mycobacterium tuberculosis Strains Harbor Missense Mutations in the Aspartate Decarboxylase PanD and the Unfoldase ClpC1
por: Gopal, Pooja, et al.
Publicado: (2017)

TBAJ-876, a 3,5-Dialkoxypyridine Analogue of Bedaquiline, Is Active against Mycobacterium abscessus
por: Sarathy, Jickky Palmae, et al.
Publicado: (2020)

Rifabutin Is Active against Mycobacterium abscessus Complex
por: Aziz, Dinah Binte, et al.
Publicado: (2017)

Cyclohexyl-griselimycin Is Active against Mycobacterium abscessus in Mice
por: Aragaw, Wassihun Wedajo, et al.
Publicado: (2022)

Efflux Pump Gene Expression in Multidrug-Resistant Mycobacterium tuberculosis Clinical Isolates
por: Li, Guilian, et al.
Publicado: (2015)

A uniform cloning platform for mycobacterial genetics and protein production
por: Arnold, Fabian M., et al.
Publicado: (2018)

Inhibition of Fatty Acid Oxidation Promotes Macrophage Control of Mycobacterium tuberculosis
por: Chandra, Pallavi, et al.
Publicado: (2020)

The effect of anti-tuberculosis drugs therapy on mRNA efflux pump gene expression of Rv1250 in Mycobacterium tuberculosis collected from tuberculosis patients
por: Umar, F., et al.
Publicado: (2019)

Heterogeneity in tuberculosis pathology, microenvironments and therapeutic responses
por: Lenaerts, Anne, et al.
Publicado: (2015)

Visualization of Mycobacterial Biomarkers and Tuberculosis Drugs in Infected Tissue by MALDI-MS Imaging
por: Blanc, Landry, et al.
Publicado: (2018)

Drug Resistance Mechanisms in Mycobacterium tuberculosis
por: Palomino, Juan Carlos, et al.
Publicado: (2014)

BCG Induces Protection against Mycobacterium tuberculosis Infection in the Wistar Rat Model
por: Singhal, Amit, et al.
Publicado: (2011)

Insights on Mycobacterium leprae Efflux Pumps and Their Implications in Drug Resistance and Virulence
por: Machado, Diana, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_7i5urmpgtm171a1m6do8a3bqal