Roles of the Exosomes Derived From Myeloid-Derived Suppressor Cells in Tumor Immunity and Cancer Progression

Tumor immunity is involved in malignant tumor progression. Myeloid-derived suppressor cells (MDSCs) play an irreplaceable role in tumor immunity. MDSCs are composed of immature myeloid cells and exhibit obvious immunomodulatory functions. Exosomes released by MDSCs (MDSCs-Exos) have similar effects...

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Autores principales: Chen, Zhuang, Yuan, Rui, Hu, Shengyun, Yuan, Weitang, Sun, Zhenqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829028/
https://www.ncbi.nlm.nih.gov/pubmed/35154134
http://dx.doi.org/10.3389/fimmu.2022.817942
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author Chen, Zhuang
Yuan, Rui
Hu, Shengyun
Yuan, Weitang
Sun, Zhenqiang
author_facet Chen, Zhuang
Yuan, Rui
Hu, Shengyun
Yuan, Weitang
Sun, Zhenqiang
author_sort Chen, Zhuang
collection PubMed
description Tumor immunity is involved in malignant tumor progression. Myeloid-derived suppressor cells (MDSCs) play an irreplaceable role in tumor immunity. MDSCs are composed of immature myeloid cells and exhibit obvious immunomodulatory functions. Exosomes released by MDSCs (MDSCs-Exos) have similar effects to parental MDSCs in regulating tumor immunity. In this review, we provided a comprehensive description of the characteristics, functions and mechanisms of exosomes. We analyzed the immunosuppressive, angiogenesis and metastatic effects of MDSCs-Exos in different tumors through multiple perspectives. Immunotherapy targeting MDSCs-Exos has demonstrated great potential in cancers and non-cancerous diseases.
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spelling pubmed-88290282022-02-11 Roles of the Exosomes Derived From Myeloid-Derived Suppressor Cells in Tumor Immunity and Cancer Progression Chen, Zhuang Yuan, Rui Hu, Shengyun Yuan, Weitang Sun, Zhenqiang Front Immunol Immunology Tumor immunity is involved in malignant tumor progression. Myeloid-derived suppressor cells (MDSCs) play an irreplaceable role in tumor immunity. MDSCs are composed of immature myeloid cells and exhibit obvious immunomodulatory functions. Exosomes released by MDSCs (MDSCs-Exos) have similar effects to parental MDSCs in regulating tumor immunity. In this review, we provided a comprehensive description of the characteristics, functions and mechanisms of exosomes. We analyzed the immunosuppressive, angiogenesis and metastatic effects of MDSCs-Exos in different tumors through multiple perspectives. Immunotherapy targeting MDSCs-Exos has demonstrated great potential in cancers and non-cancerous diseases. Frontiers Media S.A. 2022-01-27 /pmc/articles/PMC8829028/ /pubmed/35154134 http://dx.doi.org/10.3389/fimmu.2022.817942 Text en Copyright © 2022 Chen, Yuan, Hu, Yuan and Sun https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Chen, Zhuang
Yuan, Rui
Hu, Shengyun
Yuan, Weitang
Sun, Zhenqiang
Roles of the Exosomes Derived From Myeloid-Derived Suppressor Cells in Tumor Immunity and Cancer Progression
title Roles of the Exosomes Derived From Myeloid-Derived Suppressor Cells in Tumor Immunity and Cancer Progression
title_full Roles of the Exosomes Derived From Myeloid-Derived Suppressor Cells in Tumor Immunity and Cancer Progression
title_fullStr Roles of the Exosomes Derived From Myeloid-Derived Suppressor Cells in Tumor Immunity and Cancer Progression
title_full_unstemmed Roles of the Exosomes Derived From Myeloid-Derived Suppressor Cells in Tumor Immunity and Cancer Progression
title_short Roles of the Exosomes Derived From Myeloid-Derived Suppressor Cells in Tumor Immunity and Cancer Progression
title_sort roles of the exosomes derived from myeloid-derived suppressor cells in tumor immunity and cancer progression
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829028/
https://www.ncbi.nlm.nih.gov/pubmed/35154134
http://dx.doi.org/10.3389/fimmu.2022.817942
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