An in vivo Cell-Based Delivery Platform for Zinc Finger Artificial Transcription Factors in Pre-clinical Animal Models

Zinc finger (ZF), transcription activator-like effectors (TALE), and CRISPR/Cas9 therapies to regulate gene expression are becoming viable strategies to treat genetic disorders, although effective in vivo delivery systems for these proteins remain a major translational hurdle. We describe the use of...

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Detalles Bibliográficos
Autores principales: Deng, Peter, Halmai, Julian A. N. M., Beitnere, Ulrika, Cameron, David, Martinez, Michele L., Lee, Charles C., Waldo, Jennifer J., Thongphanh, Krista, Adhikari, Anna, Copping, Nycole, Petkova, Stela P., Lee, Ruth D., Lock, Samantha, Palomares, Miranda, O’Geen, Henriette, Carter, Jasmine, Gonzalez, Casiana E., Buchanan, Fiona K. B., Anderson, Johnathan D., Fierro, Fernando A., Nolta, Jan A., Tarantal, Alice F., Silverman, Jill L., Segal, David J., Fink, Kyle D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829036/
https://www.ncbi.nlm.nih.gov/pubmed/35153670
http://dx.doi.org/10.3389/fnmol.2021.789913

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