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Ten Years After SINS: Role of Surgery and Radiotherapy in the Management of Patients With Vertebral Metastases

The objective of the different types of treatments for a spinal metastasis is to provide the best oncological and functional result with the least aggressive side effects. Initially created in 2010 to help clinicians in the management of vertebral metastases, the Spine Instability Neoplastic Score (...

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Autores principales: Serratrice, Nicolas, Faddoul, Joe, Tarabay, Bilal, Attieh, Christian, Chalah, Moussa A., Ayache, Samar S., Abi Lahoud, Georges N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829066/
https://www.ncbi.nlm.nih.gov/pubmed/35155240
http://dx.doi.org/10.3389/fonc.2022.802595
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author Serratrice, Nicolas
Faddoul, Joe
Tarabay, Bilal
Attieh, Christian
Chalah, Moussa A.
Ayache, Samar S.
Abi Lahoud, Georges N.
author_facet Serratrice, Nicolas
Faddoul, Joe
Tarabay, Bilal
Attieh, Christian
Chalah, Moussa A.
Ayache, Samar S.
Abi Lahoud, Georges N.
author_sort Serratrice, Nicolas
collection PubMed
description The objective of the different types of treatments for a spinal metastasis is to provide the best oncological and functional result with the least aggressive side effects. Initially created in 2010 to help clinicians in the management of vertebral metastases, the Spine Instability Neoplastic Score (SINS) has quickly found its place in the decision making and the treatment of patients with metastatic spinal disease. Here we conduct a review of the literature describing the different changes that occurred with the SINS score in the last ten years. After a brief presentation of the spinal metastases’ distribution, with or without spinal cord compression, we present the utility of SINS in the radiological diagnosis and extension of the disease, in addition to its limits, especially for scores ranging between 7 and 12. We take this opportunity to expose the latest advances in surgery and radiotherapy concerning spinal metastases, as well as in palliative care and pain control. We also discuss the reliability of SINS amongst radiologists, radiation oncologists, spine surgeons and spine surgery trainees. Finally, we will present the new SINS-derived predictive scores, biomarkers and artificial intelligence algorithms that allow a multidisciplinary approach for the management of spinal metastases.
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spelling pubmed-88290662022-02-11 Ten Years After SINS: Role of Surgery and Radiotherapy in the Management of Patients With Vertebral Metastases Serratrice, Nicolas Faddoul, Joe Tarabay, Bilal Attieh, Christian Chalah, Moussa A. Ayache, Samar S. Abi Lahoud, Georges N. Front Oncol Oncology The objective of the different types of treatments for a spinal metastasis is to provide the best oncological and functional result with the least aggressive side effects. Initially created in 2010 to help clinicians in the management of vertebral metastases, the Spine Instability Neoplastic Score (SINS) has quickly found its place in the decision making and the treatment of patients with metastatic spinal disease. Here we conduct a review of the literature describing the different changes that occurred with the SINS score in the last ten years. After a brief presentation of the spinal metastases’ distribution, with or without spinal cord compression, we present the utility of SINS in the radiological diagnosis and extension of the disease, in addition to its limits, especially for scores ranging between 7 and 12. We take this opportunity to expose the latest advances in surgery and radiotherapy concerning spinal metastases, as well as in palliative care and pain control. We also discuss the reliability of SINS amongst radiologists, radiation oncologists, spine surgeons and spine surgery trainees. Finally, we will present the new SINS-derived predictive scores, biomarkers and artificial intelligence algorithms that allow a multidisciplinary approach for the management of spinal metastases. Frontiers Media S.A. 2022-01-27 /pmc/articles/PMC8829066/ /pubmed/35155240 http://dx.doi.org/10.3389/fonc.2022.802595 Text en Copyright © 2022 Serratrice, Faddoul, Tarabay, Attieh, Chalah, Ayache and Abi Lahoud https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Serratrice, Nicolas
Faddoul, Joe
Tarabay, Bilal
Attieh, Christian
Chalah, Moussa A.
Ayache, Samar S.
Abi Lahoud, Georges N.
Ten Years After SINS: Role of Surgery and Radiotherapy in the Management of Patients With Vertebral Metastases
title Ten Years After SINS: Role of Surgery and Radiotherapy in the Management of Patients With Vertebral Metastases
title_full Ten Years After SINS: Role of Surgery and Radiotherapy in the Management of Patients With Vertebral Metastases
title_fullStr Ten Years After SINS: Role of Surgery and Radiotherapy in the Management of Patients With Vertebral Metastases
title_full_unstemmed Ten Years After SINS: Role of Surgery and Radiotherapy in the Management of Patients With Vertebral Metastases
title_short Ten Years After SINS: Role of Surgery and Radiotherapy in the Management of Patients With Vertebral Metastases
title_sort ten years after sins: role of surgery and radiotherapy in the management of patients with vertebral metastases
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829066/
https://www.ncbi.nlm.nih.gov/pubmed/35155240
http://dx.doi.org/10.3389/fonc.2022.802595
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