Development of the Human Arterial Valves: Understanding Bicuspid Aortic Valve

Abnormalities in the arterial valves are some of the commonest congenital malformations, with bicuspid aortic valve (BAV) occurring in as many as 2% of the population. Despite this, most of what we understand about the development of the arterial (semilunar; aortic and pulmonary) valves is extrapola...

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Autores principales: Henderson, Deborah J., Eley, Lorraine, Turner, Jasmin E., Chaudhry, Bill
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829322/
https://www.ncbi.nlm.nih.gov/pubmed/35155611
http://dx.doi.org/10.3389/fcvm.2021.802930
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author Henderson, Deborah J.
Eley, Lorraine
Turner, Jasmin E.
Chaudhry, Bill
author_facet Henderson, Deborah J.
Eley, Lorraine
Turner, Jasmin E.
Chaudhry, Bill
author_sort Henderson, Deborah J.
collection PubMed
description Abnormalities in the arterial valves are some of the commonest congenital malformations, with bicuspid aortic valve (BAV) occurring in as many as 2% of the population. Despite this, most of what we understand about the development of the arterial (semilunar; aortic and pulmonary) valves is extrapolated from investigations of the atrioventricular valves in animal models, with surprisingly little specifically known about how the arterial valves develop in mouse, and even less in human. In this review, we summarise what is known about the development of the human arterial valve leaflets, comparing this to the mouse where appropriate.
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spelling pubmed-88293222022-02-11 Development of the Human Arterial Valves: Understanding Bicuspid Aortic Valve Henderson, Deborah J. Eley, Lorraine Turner, Jasmin E. Chaudhry, Bill Front Cardiovasc Med Cardiovascular Medicine Abnormalities in the arterial valves are some of the commonest congenital malformations, with bicuspid aortic valve (BAV) occurring in as many as 2% of the population. Despite this, most of what we understand about the development of the arterial (semilunar; aortic and pulmonary) valves is extrapolated from investigations of the atrioventricular valves in animal models, with surprisingly little specifically known about how the arterial valves develop in mouse, and even less in human. In this review, we summarise what is known about the development of the human arterial valve leaflets, comparing this to the mouse where appropriate. Frontiers Media S.A. 2022-01-27 /pmc/articles/PMC8829322/ /pubmed/35155611 http://dx.doi.org/10.3389/fcvm.2021.802930 Text en Copyright © 2022 Henderson, Eley, Turner and Chaudhry. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Henderson, Deborah J.
Eley, Lorraine
Turner, Jasmin E.
Chaudhry, Bill
Development of the Human Arterial Valves: Understanding Bicuspid Aortic Valve
title Development of the Human Arterial Valves: Understanding Bicuspid Aortic Valve
title_full Development of the Human Arterial Valves: Understanding Bicuspid Aortic Valve
title_fullStr Development of the Human Arterial Valves: Understanding Bicuspid Aortic Valve
title_full_unstemmed Development of the Human Arterial Valves: Understanding Bicuspid Aortic Valve
title_short Development of the Human Arterial Valves: Understanding Bicuspid Aortic Valve
title_sort development of the human arterial valves: understanding bicuspid aortic valve
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829322/
https://www.ncbi.nlm.nih.gov/pubmed/35155611
http://dx.doi.org/10.3389/fcvm.2021.802930
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