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PIWI-Interacting RNAs (piRNAs): Promising Applications as Emerging Biomarkers for Digestive System Cancer

PIWI-interacting RNAs (piRNAs) are a novel type of small non-coding RNAs (sncRNAs), which are 26–31 nucleotides in length and bind to PIWI proteins. Although piRNAs were originally discovered in germline cells and are thought to be essential regulators for germline preservation, they can also influe...

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Autores principales: Cai, Aiting, Hu, Yuhao, Zhou, Zhou, Qi, Qianyi, Wu, Yixuan, Dong, Peixin, Chen, Lin, Wang, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829394/
https://www.ncbi.nlm.nih.gov/pubmed/35155584
http://dx.doi.org/10.3389/fmolb.2022.848105
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author Cai, Aiting
Hu, Yuhao
Zhou, Zhou
Qi, Qianyi
Wu, Yixuan
Dong, Peixin
Chen, Lin
Wang, Feng
author_facet Cai, Aiting
Hu, Yuhao
Zhou, Zhou
Qi, Qianyi
Wu, Yixuan
Dong, Peixin
Chen, Lin
Wang, Feng
author_sort Cai, Aiting
collection PubMed
description PIWI-interacting RNAs (piRNAs) are a novel type of small non-coding RNAs (sncRNAs), which are 26–31 nucleotides in length and bind to PIWI proteins. Although piRNAs were originally discovered in germline cells and are thought to be essential regulators for germline preservation, they can also influence gene expression in somatic cells. An increasing amount of data has shown that the dysregulation of piRNAs can both promote and repress the emergence and progression of human cancers through DNA methylation, transcriptional silencing, mRNA turnover, and translational control. Digestive cancers are currently a major cause of cancer deaths worldwide. piRNAs control the expression of essential genes and pathways associated with digestive cancer progression and have been reported as possible biomarkers for the diagnosis and treatment of digestive cancer. Here, we highlight recent advances in understanding the involvement of piRNAs, as well as potential diagnostic and therapeutic applications of piRNAs in various digestive cancers.
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spelling pubmed-88293942022-02-11 PIWI-Interacting RNAs (piRNAs): Promising Applications as Emerging Biomarkers for Digestive System Cancer Cai, Aiting Hu, Yuhao Zhou, Zhou Qi, Qianyi Wu, Yixuan Dong, Peixin Chen, Lin Wang, Feng Front Mol Biosci Molecular Biosciences PIWI-interacting RNAs (piRNAs) are a novel type of small non-coding RNAs (sncRNAs), which are 26–31 nucleotides in length and bind to PIWI proteins. Although piRNAs were originally discovered in germline cells and are thought to be essential regulators for germline preservation, they can also influence gene expression in somatic cells. An increasing amount of data has shown that the dysregulation of piRNAs can both promote and repress the emergence and progression of human cancers through DNA methylation, transcriptional silencing, mRNA turnover, and translational control. Digestive cancers are currently a major cause of cancer deaths worldwide. piRNAs control the expression of essential genes and pathways associated with digestive cancer progression and have been reported as possible biomarkers for the diagnosis and treatment of digestive cancer. Here, we highlight recent advances in understanding the involvement of piRNAs, as well as potential diagnostic and therapeutic applications of piRNAs in various digestive cancers. Frontiers Media S.A. 2022-01-27 /pmc/articles/PMC8829394/ /pubmed/35155584 http://dx.doi.org/10.3389/fmolb.2022.848105 Text en Copyright © 2022 Cai, Hu, Zhou, Qi, Wu, Dong, Chen and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Cai, Aiting
Hu, Yuhao
Zhou, Zhou
Qi, Qianyi
Wu, Yixuan
Dong, Peixin
Chen, Lin
Wang, Feng
PIWI-Interacting RNAs (piRNAs): Promising Applications as Emerging Biomarkers for Digestive System Cancer
title PIWI-Interacting RNAs (piRNAs): Promising Applications as Emerging Biomarkers for Digestive System Cancer
title_full PIWI-Interacting RNAs (piRNAs): Promising Applications as Emerging Biomarkers for Digestive System Cancer
title_fullStr PIWI-Interacting RNAs (piRNAs): Promising Applications as Emerging Biomarkers for Digestive System Cancer
title_full_unstemmed PIWI-Interacting RNAs (piRNAs): Promising Applications as Emerging Biomarkers for Digestive System Cancer
title_short PIWI-Interacting RNAs (piRNAs): Promising Applications as Emerging Biomarkers for Digestive System Cancer
title_sort piwi-interacting rnas (pirnas): promising applications as emerging biomarkers for digestive system cancer
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829394/
https://www.ncbi.nlm.nih.gov/pubmed/35155584
http://dx.doi.org/10.3389/fmolb.2022.848105
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