Cargando…

Theta-Defensins to Counter COVID-19 as Furin Inhibitors: In Silico Efficiency Prediction and Novel Compound Design

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was characterized as a pandemic by the World Health Organization (WHO) in Dec. 2019. SARS-CoV-2 binds to the cell membrane through spike proteins on its surface and infects the cell. Furin, a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Negahdaripour, Manica, Rahbar, Mohammad Reza, Mosalanejad, Zahra, Gholami, Ahmad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829439/ https://www.ncbi.nlm.nih.gov/pubmed/35154362 http://dx.doi.org/10.1155/2022/9735626

Ejemplares similares

The interactions of folate with the enzyme furin: a computational study
por: Sheybani, Zahra, et al.
Publicado: (2021)

Modeling and affinity maturation of an anti-CD20 nanobody: a comprehensive in-silico investigation
por: Poustforoosh, Alireza, et al.
Publicado: (2023)

In silico design and evaluation of a novel mRNA vaccine against BK virus: a reverse vaccinology approach
por: Mohammadi, Yasaman, et al.
Publicado: (2022)

In-Silico Tool for Predicting, Scanning, and Designing Defensins
por: Kaur, Dilraj, et al.
Publicado: (2021)

Iranian Journal of Medical Sciences: 2021 Review and 2022 Outlook
por: Mahdiyar, Zahra, et al.
Publicado: (2022)

The Rise and Fall in Therapeutic Candidates for COVID-19
por: Negahdaripour, Manica
Publicado: (2020)

The Battle Against COVID-19: Where Do We Stand Now?
por: Negahdaripour, Manica
Publicado: (2020)

A World of Changes: The Inheritance of COVID-19
por: Negahdaripour, Manica
Publicado: (2020)

Fifty Years of Witnessing Biomedical Science Developments
por: Negahdaripour, Manica
Publicado: (2020)

COVID-19 Vaccine Global Access Is an Urgency
por: Negahdaripour, Manica
Publicado: (2021)

Post-COVID-19 Hyperglycemia: A Concern in Selection of Therapeutic Regimens
por: Negahdaripour, Manica
Publicado: (2021)

Deep survey for designing a vaccine against SARS-CoV-2 and its new mutations
por: Vakili, Bahareh, et al.
Publicado: (2021)

Non-adaptive Evolution of Trimeric Autotransporters in Brucellaceae
por: Rahbar, Mohammad Reza, et al.
Publicado: (2020)

Cationic Cell-Penetrating Peptides Are Potent Furin Inhibitors
por: Ramos-Molina, Bruno, et al.
Publicado: (2015)

Cyclic Peptidic Furin Inhibitors Developed by Combinatorial Chemistry
por: Gitlin-Domagalska, Agata, et al.
Publicado: (2023)

A perspective on the applications of furin inhibitors for the treatment of SARS-CoV-2
por: Devi, Kasi Pandima, et al.
Publicado: (2022)

Insights into Omicron’s Low Fusogenicity through In Silico Molecular Studies on Spike-Furin Interactions
por: Mondol, Spencer Mark, et al.
Publicado: (2023)

Rhesus Macaque Theta Defensins Suppress Inflammatory Cytokines and Enhance Survival in Mouse Models of Bacteremic Sepsis
por: Schaal, Justin B., et al.
Publicado: (2012)

Theta-Defensins Inhibit High-Risk Human Papillomavirus Infection Through Charge-Driven Capsid Clustering
por: Skeate, Joseph G., et al.
Publicado: (2020)

Rhesus Theta Defensin 1 Promotes Long Term Survival in Systemic Candidiasis by Host Directed Mechanisms
por: Basso, Virginia, et al.
Publicado: (2019)

Inhibition of miR-146a Expression and Regulation of Endotoxin Tolerance by Rhesus Theta-Defensin-1
por: Tongaonkar, Prasad, et al.
Publicado: (2023)

X-ray Structures of Human Furin in Complex with Competitive Inhibitors
por: Dahms, Sven O., et al.
Publicado: (2014)

Effect of Furin inhibitor on lung adenocarcinoma cell growth and metastasis
por: Ma, Yong-Chao, et al.
Publicado: (2014)

Identification of Kukoamine A, Zeaxanthin, and Clexane as New Furin Inhibitors
por: Zaragoza-Huesca, David, et al.
Publicado: (2022)

Immunotherapeutic approaches to curtail COVID-19
por: Owji, Hajar, et al.
Publicado: (2020)

A systems biology approach for discovering the cellular and molecular aspects of psychogenic non-epileptic seizure
por: Malekpour, Mahdi, et al.
Publicado: (2023)

Investigation on the processing and improving the cleavage efficiency of furin cleavage sites in Pichia pastoris
por: Huang, Yide, et al.
Publicado: (2018)

Hotspots for mutations in the SARS-CoV-2 spike glycoprotein: a correspondence analysis
por: Rahbar, Mohammad Reza, et al.
Publicado: (2021)

Harnessing self-assembled peptide nanoparticles in epitope vaccine design
por: Negahdaripour, Manica, et al.
Publicado: (2017)

Identification of hub pathways and drug candidates in gastric cancer through systems biology
por: Salarikia, Seyed Reza, et al.
Publicado: (2022)

In silico characterization of cysteine-stabilized αβ defensins from neglected unicellular microeukaryotes
por: Senra, Marcus Vinicius Xavier
Publicado: (2023)

Analytical methodologies for determination of methotrexate and its metabolites in pharmaceutical, biological and environmental samples
por: Karami, Forough, et al.
Publicado: (2019)

An efficient anticoincidence counter
Publicado: (1977)

FurinDB: A Database of 20-Residue Furin Cleavage Site Motifs, Substrates and Their Associated Drugs
por: Tian, Sun, et al.
Publicado: (2011)

The Basicity Makes the Difference: Improved Canavanine-Derived Inhibitors of the Proprotein Convertase Furin
por: Lam van, Thuy Van, et al.
Publicado: (2021)

Mouse β-Defensin 3, A Defensin Inhibitor of Both Its Endogenous and Exogenous Potassium Channels
por: Zhang, Yaoyun, et al.
Publicado: (2018)

Influence of a Coronary Artery Disease–Associated Genetic Variant on FURIN Expression and Effect of Furin on Macrophage Behavior
por: Zhao, Guojun, et al.
Publicado: (2018)

In silico targeting of red complex bacteria virulence factors of periodontitis with β-defensin 1
por: Venkata Subbiah, Harini, et al.
Publicado: (2022)

Furin inhibitor protects against neuronal cell death induced by activated NMDA receptors
por: Yamada, Mariko, et al.
Publicado: (2018)

The Path to Therapeutic Furin Inhibitors: From Yeast Pheromones to SARS-CoV-2
por: Thomas, Gary, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_5pq82sht0k9ken3qhsd9ldg7fa