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Purine-Induced IFN-γ Promotes Uric Acid Production by Upregulating Xanthine Oxidoreductase Expression

OBJECTIVE: Limiting purine intake, inhibiting xanthine oxidoreductase (XOR) and inhibiting urate reabsorption in proximal tubule by uricosuric drugs, to reduce serum uric acid (UA) levels, are recognized treatments for gout. However, the mechanism of increased how XOR expression and activity in hype...

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Detalles Bibliográficos
Autores principales:	Wang, Huanhuan, Xie, Lingzhu, Song, Xuhong, Wang, Jing, Li, Xinyan, Lin, Zhike, Su, Ting, Liang, Bin, Huang, Dongyang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829549/ https://www.ncbi.nlm.nih.gov/pubmed/35154100 http://dx.doi.org/10.3389/fimmu.2022.773001

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