PiggyBac Transposon-Mediated CD19 Chimeric Antigen Receptor-T Cells Derived From CD45RA-Positive Peripheral Blood Mononuclear Cells Possess Potent and Sustained Antileukemic Function

The quality of chimeric antigen receptor (CAR)-T cell products, namely, memory and exhaustion markers, affects the long-term functionality of CAR-T cells. We previously reported that piggyBac (PB) transposon-mediated CD19 CAR-T cells exhibit a memory-rich phenotype that is characterized by the high...

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Detalles Bibliográficos
Autores principales: Suematsu, Masaya, Yagyu, Shigeki, Nagao, Nobuyoshi, Kubota, Susumu, Shimizu, Yuto, Tanaka, Miyuki, Nakazawa, Yozo, Imamura, Toshihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829551/
https://www.ncbi.nlm.nih.gov/pubmed/35154098
http://dx.doi.org/10.3389/fimmu.2022.770132

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