Dichloroacetate, a pyruvate dehydrogenase kinase inhibitor, ameliorates type 2 diabetes via reduced gluconeogenesis

AIMS: Pyruvate dehydrogenase (PDH) catalyzes the decarboxylation of pyruvate to acetyl-CoA, which plays a key role in linking cytosolic glycolysis to mitochondria metabolism. PDH is physiologically inactivated by pyruvate dehydrogenase kinases (PDKs). Thus, activation of PDH via inhibiting PDK may l...

Descripción completa

Detalles Bibliográficos
Autores principales: Katayama, Yuko, Kawata, Yayoi, Moritoh, Yusuke, Watanabe, Masanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829582/
https://www.ncbi.nlm.nih.gov/pubmed/35169648
http://dx.doi.org/10.1016/j.heliyon.2022.e08889

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829582/
https://www.ncbi.nlm.nih.gov/pubmed/35169648
http://dx.doi.org/10.1016/j.heliyon.2022.e08889

Ejemplares similares