Cargando…

Dichloroacetate, a pyruvate dehydrogenase kinase inhibitor, ameliorates type 2 diabetes via reduced gluconeogenesis

AIMS: Pyruvate dehydrogenase (PDH) catalyzes the decarboxylation of pyruvate to acetyl-CoA, which plays a key role in linking cytosolic glycolysis to mitochondria metabolism. PDH is physiologically inactivated by pyruvate dehydrogenase kinases (PDKs). Thus, activation of PDH via inhibiting PDK may l...

Descripción completa

Detalles Bibliográficos
Autores principales:	Katayama, Yuko, Kawata, Yayoi, Moritoh, Yusuke, Watanabe, Masanori
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829582/ https://www.ncbi.nlm.nih.gov/pubmed/35169648 http://dx.doi.org/10.1016/j.heliyon.2022.e08889

Ejemplares similares

Dichloroacetate and Pyruvate Metabolism: Pyruvate Dehydrogenase Kinases as Targets Worth Investigating for Effective Therapy of Toxoplasmosis
por: Ferrarini, Mariana Galvão, et al.
Publicado: (2021)

Pyruvate Dehydrogenase Kinase Inhibition by Dichloroacetate in Melanoma Cells Unveils Metabolic Vulnerabilities
por: Tiersma, Jiske F., et al.
Publicado: (2022)

Dichloroacetate, the Pyruvate Dehydrogenase Complex and the Modulation of mESC Pluripotency
por: Rodrigues, Ana Sofia, et al.
Publicado: (2015)

Comparison Between Dichloroacetate and Phenylbutyrate Treatment for Pyruvate Dehydrogenase Deficiency
por: Karissa, Patricia, et al.
Publicado: (2022)

Cobalt-conjugated carbon quantum dots for in vivo monitoring of the pyruvate dehydrogenase kinase inhibitor drug dichloroacetic acid
por: Raut, Jiko, et al.
Publicado: (2022)

Pyruvate Dehydrogenase Kinase Inhibitor Dichloroacetate Improves Host Control of Salmonella enterica Serovar Typhimurium Infection in Human Macrophages
por: van Doorn, Cassandra L. R., et al.
Publicado: (2021)

Regulation of Muscle Pyruvate Dehydrogenase Complex in Insulin Resistance: Effects of Exercise and Dichloroacetate
por: Constantin-Teodosiu, Dumitru
Publicado: (2013)

Differential inhibition of PDKs by phenylbutyrate and enhancement of pyruvate dehydrogenase complex activity by combination with dichloroacetate
por: Ferriero, Rosa, et al.
Publicado: (2015)

Diisopropylamine Dichloroacetate, a Novel Pyruvate Dehydrogenase Kinase 4 Inhibitor, as a Potential Therapeutic Agent for Metabolic Disorders and Multiorgan Failure in Severe Influenza
por: Yamane, Kazuhiko, et al.
Publicado: (2014)

Suppression of Pyruvate Dehydrogenase Kinase by Dichloroacetate in Cancer and Skeletal Muscle Cells Is Isoform Specific and Partially Independent of HIF-1α
por: Škorja Milić, Nives, et al.
Publicado: (2021)

Enteropeptidase inhibition improves kidney function in a rat model of diabetic kidney disease
por: Sugama, Jun, et al.
Publicado: (2020)

Targeting Pyruvate Carboxylase Reduces Gluconeogenesis and Adiposity and Improves Insulin Resistance
por: Kumashiro, Naoki, et al.
Publicado: (2013)

Transcriptional Regulation of Pyruvate Dehydrogenase Kinase
por: Jeong, Ji Yun, et al.
Publicado: (2012)

Enteropeptidase inhibitor SCO-792 effectively prevents kidney function decline and fibrosis in a rat model of chronic kidney disease
por: Katayama, Yuko, et al.
Publicado: (2020)

Inhibition of Pyruvate Dehydrogenase Kinase 4 in CD4(+) T Cells Ameliorates Intestinal Inflammation
por: Lee, Hoyul, et al.
Publicado: (2022)

Computational Study on New Natural Compound Inhibitors of Pyruvate Dehydrogenase Kinases
por: Zhou, Xiaoli, et al.
Publicado: (2016)

Combined Treatment With Dichloroacetic Acid and Pyruvate Reduces Hippocampal Neuronal Death After Transient Cerebral Ischemia
por: Hong, Dae Ki, et al.
Publicado: (2018)

The Role of Pyruvate Dehydrogenase Kinase in Diabetes and Obesity
por: Lee, In-Kyu
Publicado: (2014)

Combined Treatment of Dichloroacetic Acid and Pyruvate Increased Neuronal Survival after Seizure
por: Lee, Song Hee, et al.
Publicado: (2022)

The pivotal role of pyruvate dehydrogenase kinases in metabolic flexibility
por: Zhang, Shuai, et al.
Publicado: (2014)

Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers
por: Jeoung, Nam Ho
Publicado: (2015)

Refining the Role of Pyruvate Dehydrogenase Kinases in Glioblastoma Development
por: Larrieu, Claire M., et al.
Publicado: (2022)

Pyruvate Dehydrogenase Inhibition Leads to Decreased Glycolysis, Increased Reliance on Gluconeogenesis and Alternative Sources of Acetyl-CoA in Acute Myeloid Leukemia
por: Anderson, Rebecca, et al.
Publicado: (2023)

Asp295 Stabilizes the Active-Site Loop Structure of Pyruvate Dehydrogenase, Facilitating Phosphorylation of Ser292 by Pyruvate Dehydrogenase-Kinase
por: Hirani, Tripty A., et al.
Publicado: (2011)

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase
por: Madiraju, Anila K., et al.
Publicado: (2014)

Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology
por: Sutendra, Gopinath, et al.
Publicado: (2013)

Pyruvate dehydrogenase kinase regulates hepatitis C virus replication
por: Jung, Gwon-Soo, et al.
Publicado: (2016)

Pyruvate dehydrogenase kinases (PDKs): an overview toward clinical applications
por: Wang, Xiuxiu, et al.
Publicado: (2021)

Activating oxidative phosphorylation by a pyruvate dehydrogenase kinase inhibitor overcomes sorafenib resistance of hepatocellular carcinoma
por: Shen, Y-C, et al.
Publicado: (2013)

Discovery of Hordenine as a Potential Inhibitor of Pyruvate Dehydrogenase Kinase 3: Implication in Lung Cancer Therapy
por: Anwar, Saleha, et al.
Publicado: (2020)

Ilimaquinone Induces the Apoptotic Cell Death of Cancer Cells by Reducing Pyruvate Dehydrogenase Kinase 1 Activity
por: Kwak, Choong-Hwan, et al.
Publicado: (2020)

Role of Pyruvate Dehydrogenase Kinase 4 in Regulation of Blood Glucose Levels
por: Jeoung, Nam Ho, et al.
Publicado: (2010)

Pyruvate Dehydrogenase Kinase as a Potential Therapeutic Target for Malignant Gliomas
por: Jha, Mithilesh Kumar, et al.
Publicado: (2013)

Mechanisms of Vascular Calcification: The Pivotal Role of Pyruvate Dehydrogenase Kinase 4
por: Leem, Jaechan, et al.
Publicado: (2016)

Global view of cognate kinase activation by the human pyruvate dehydrogenase complex
por: Guevara, Elena L., et al.
Publicado: (2017)

Reversing tozasertib resistance in glioma through inhibition of pyruvate dehydrogenase kinases
por: Jane, Esther P., et al.
Publicado: (2021)

Modulation of Muscle Fiber Compositions in Response to Hypoxia via Pyruvate Dehydrogenase Kinase-1
por: Nguyen, Daniel D., et al.
Publicado: (2016)

Pro-haloacetate Nanoparticles for Efficient Cancer Therapy via Pyruvate Dehydrogenase Kinase Modulation
por: Misra, Santosh K., et al.
Publicado: (2016)

Endogenous renal adiponectin drives gluconeogenesis through enhancing pyruvate and fatty acid utilization
por: Onodera, Toshiharu, et al.
Publicado: (2023)

Effects of hepatic mitochondrial pyruvate carrier deficiency on de novo lipogenesis and gluconeogenesis in mice
por: Yiew, Nicole K.H., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_4c624i0ggihbqj9um8du86l61n