Functional Rescue of a Nephrogenic Diabetes Insipidus Causing Mutation in the V2 Vasopressin Receptor by Specific Antagonist and Agonist Pharmacochaperones

The urine concentrating function of the kidney is essential to maintain the water homeostasis of the human body. It is mainly regulated by the arginine-vasopressin (AVP), which targets the type 2 vasopressin receptor (V2R) in the kidney. The inability of V2R to respond to AVP stimulation leads to de...

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Detalles Bibliográficos
Autores principales: Szalai, Laura, Sziráki, András, Erdélyi, László Sándor, Kovács, Kinga Bernadett, Tóth, Miklós, Tóth, András Dávid, Turu, Gábor, Bonnet, Dominique, Mouillac, Bernard, Hunyady, László, Balla, András
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829706/
https://www.ncbi.nlm.nih.gov/pubmed/35153784
http://dx.doi.org/10.3389/fphar.2022.811836

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