Differential T cell immune responses to deamidated adeno-associated virus vector

Despite the high safety profile demonstrated in clinical trials, the immunogenicity of adeno-associated virus (AAV)-mediated gene therapy remains a major hurdle. Specifically, T-cell-mediated immune responses to AAV vectors are related to loss of efficacy and potential liver toxicities. As post-tran...

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Detalles Bibliográficos
Autores principales: Bing, So Jin, Justesen, Sune, Wu, Wells W., Sajib, Abdul Mohin, Warrington, Stephanee, Baer, Alan, Thorgrimsen, Stephan, Shen, Rong-Fong, Mazor, Ronit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829777/
https://www.ncbi.nlm.nih.gov/pubmed/35211638
http://dx.doi.org/10.1016/j.omtm.2022.01.005

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