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Transcranial pulse stimulation (TPS) improves depression in AD patients on state‐of‐the‐art treatment

INTRODUCTION: Ultrasound‐based brain stimulation is a novel, non‐invasive therapeutic approach to precisely target regions of interest. Data from a first clinical trial of patients with Alzheimer's disease (AD) receiving 2‐4 weeks transcranial pulse stimulation (TPS) have shown memory and cogni...

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Autores principales: Matt, Eva, Dörl, Gregor, Beisteiner, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829892/
https://www.ncbi.nlm.nih.gov/pubmed/35169611
http://dx.doi.org/10.1002/trc2.12245
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author Matt, Eva
Dörl, Gregor
Beisteiner, Roland
author_facet Matt, Eva
Dörl, Gregor
Beisteiner, Roland
author_sort Matt, Eva
collection PubMed
description INTRODUCTION: Ultrasound‐based brain stimulation is a novel, non‐invasive therapeutic approach to precisely target regions of interest. Data from a first clinical trial of patients with Alzheimer's disease (AD) receiving 2‐4 weeks transcranial pulse stimulation (TPS) have shown memory and cognitive improvements for up to 3 months, despite ongoing state‐of‐the‐art treatment. Importantly, depressive symptoms also improved. METHODS: We analyzed changes in Beck Depression Inventory (BDI‐II) and functional connectivity (FC) changes with functional magnetic resonance imaging in 18 AD patients. RESULTS: We found significant improvement in BDI‐II after TPS therapy. FC analysis showed a normalization of the FC between the salience network (right anterior insula) and the ventromedial network (left frontal orbital cortex). DISCUSSION: Stimulation of areas related to depression (including extended dorsolateral prefrontal cortex) appears to alleviate depressive symptoms and induces FC changes in AD patients. TPS may be a novel add‐on therapy for depression in AD and as a neuropsychiatric diagnosis.
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spelling pubmed-88298922022-02-14 Transcranial pulse stimulation (TPS) improves depression in AD patients on state‐of‐the‐art treatment Matt, Eva Dörl, Gregor Beisteiner, Roland Alzheimers Dement (N Y) Short Report INTRODUCTION: Ultrasound‐based brain stimulation is a novel, non‐invasive therapeutic approach to precisely target regions of interest. Data from a first clinical trial of patients with Alzheimer's disease (AD) receiving 2‐4 weeks transcranial pulse stimulation (TPS) have shown memory and cognitive improvements for up to 3 months, despite ongoing state‐of‐the‐art treatment. Importantly, depressive symptoms also improved. METHODS: We analyzed changes in Beck Depression Inventory (BDI‐II) and functional connectivity (FC) changes with functional magnetic resonance imaging in 18 AD patients. RESULTS: We found significant improvement in BDI‐II after TPS therapy. FC analysis showed a normalization of the FC between the salience network (right anterior insula) and the ventromedial network (left frontal orbital cortex). DISCUSSION: Stimulation of areas related to depression (including extended dorsolateral prefrontal cortex) appears to alleviate depressive symptoms and induces FC changes in AD patients. TPS may be a novel add‐on therapy for depression in AD and as a neuropsychiatric diagnosis. John Wiley and Sons Inc. 2022-02-10 /pmc/articles/PMC8829892/ /pubmed/35169611 http://dx.doi.org/10.1002/trc2.12245 Text en © 2022 The Authors. Alzheimer's & Dementia: Translational Research & Clinical Interventions published by Wiley Periodicals LLC on behalf of Alzheimer's Association. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Report
Matt, Eva
Dörl, Gregor
Beisteiner, Roland
Transcranial pulse stimulation (TPS) improves depression in AD patients on state‐of‐the‐art treatment
title Transcranial pulse stimulation (TPS) improves depression in AD patients on state‐of‐the‐art treatment
title_full Transcranial pulse stimulation (TPS) improves depression in AD patients on state‐of‐the‐art treatment
title_fullStr Transcranial pulse stimulation (TPS) improves depression in AD patients on state‐of‐the‐art treatment
title_full_unstemmed Transcranial pulse stimulation (TPS) improves depression in AD patients on state‐of‐the‐art treatment
title_short Transcranial pulse stimulation (TPS) improves depression in AD patients on state‐of‐the‐art treatment
title_sort transcranial pulse stimulation (tps) improves depression in ad patients on state‐of‐the‐art treatment
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829892/
https://www.ncbi.nlm.nih.gov/pubmed/35169611
http://dx.doi.org/10.1002/trc2.12245
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