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Transcranial pulse stimulation (TPS) improves depression in AD patients on state‐of‐the‐art treatment
INTRODUCTION: Ultrasound‐based brain stimulation is a novel, non‐invasive therapeutic approach to precisely target regions of interest. Data from a first clinical trial of patients with Alzheimer's disease (AD) receiving 2‐4 weeks transcranial pulse stimulation (TPS) have shown memory and cogni...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829892/ https://www.ncbi.nlm.nih.gov/pubmed/35169611 http://dx.doi.org/10.1002/trc2.12245 |
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author | Matt, Eva Dörl, Gregor Beisteiner, Roland |
author_facet | Matt, Eva Dörl, Gregor Beisteiner, Roland |
author_sort | Matt, Eva |
collection | PubMed |
description | INTRODUCTION: Ultrasound‐based brain stimulation is a novel, non‐invasive therapeutic approach to precisely target regions of interest. Data from a first clinical trial of patients with Alzheimer's disease (AD) receiving 2‐4 weeks transcranial pulse stimulation (TPS) have shown memory and cognitive improvements for up to 3 months, despite ongoing state‐of‐the‐art treatment. Importantly, depressive symptoms also improved. METHODS: We analyzed changes in Beck Depression Inventory (BDI‐II) and functional connectivity (FC) changes with functional magnetic resonance imaging in 18 AD patients. RESULTS: We found significant improvement in BDI‐II after TPS therapy. FC analysis showed a normalization of the FC between the salience network (right anterior insula) and the ventromedial network (left frontal orbital cortex). DISCUSSION: Stimulation of areas related to depression (including extended dorsolateral prefrontal cortex) appears to alleviate depressive symptoms and induces FC changes in AD patients. TPS may be a novel add‐on therapy for depression in AD and as a neuropsychiatric diagnosis. |
format | Online Article Text |
id | pubmed-8829892 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88298922022-02-14 Transcranial pulse stimulation (TPS) improves depression in AD patients on state‐of‐the‐art treatment Matt, Eva Dörl, Gregor Beisteiner, Roland Alzheimers Dement (N Y) Short Report INTRODUCTION: Ultrasound‐based brain stimulation is a novel, non‐invasive therapeutic approach to precisely target regions of interest. Data from a first clinical trial of patients with Alzheimer's disease (AD) receiving 2‐4 weeks transcranial pulse stimulation (TPS) have shown memory and cognitive improvements for up to 3 months, despite ongoing state‐of‐the‐art treatment. Importantly, depressive symptoms also improved. METHODS: We analyzed changes in Beck Depression Inventory (BDI‐II) and functional connectivity (FC) changes with functional magnetic resonance imaging in 18 AD patients. RESULTS: We found significant improvement in BDI‐II after TPS therapy. FC analysis showed a normalization of the FC between the salience network (right anterior insula) and the ventromedial network (left frontal orbital cortex). DISCUSSION: Stimulation of areas related to depression (including extended dorsolateral prefrontal cortex) appears to alleviate depressive symptoms and induces FC changes in AD patients. TPS may be a novel add‐on therapy for depression in AD and as a neuropsychiatric diagnosis. John Wiley and Sons Inc. 2022-02-10 /pmc/articles/PMC8829892/ /pubmed/35169611 http://dx.doi.org/10.1002/trc2.12245 Text en © 2022 The Authors. Alzheimer's & Dementia: Translational Research & Clinical Interventions published by Wiley Periodicals LLC on behalf of Alzheimer's Association. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Report Matt, Eva Dörl, Gregor Beisteiner, Roland Transcranial pulse stimulation (TPS) improves depression in AD patients on state‐of‐the‐art treatment |
title | Transcranial pulse stimulation (TPS) improves depression in AD patients on state‐of‐the‐art treatment |
title_full | Transcranial pulse stimulation (TPS) improves depression in AD patients on state‐of‐the‐art treatment |
title_fullStr | Transcranial pulse stimulation (TPS) improves depression in AD patients on state‐of‐the‐art treatment |
title_full_unstemmed | Transcranial pulse stimulation (TPS) improves depression in AD patients on state‐of‐the‐art treatment |
title_short | Transcranial pulse stimulation (TPS) improves depression in AD patients on state‐of‐the‐art treatment |
title_sort | transcranial pulse stimulation (tps) improves depression in ad patients on state‐of‐the‐art treatment |
topic | Short Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8829892/ https://www.ncbi.nlm.nih.gov/pubmed/35169611 http://dx.doi.org/10.1002/trc2.12245 |
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